Vos G H, Brain P, Vos D, Marimuthu T
Transfusion. 1979 Sep-Oct;19(5):572-6. doi: 10.1046/j.1537-2995.1979.19580059812.x.
Group A, B and O subjects who produce immune antibodies to group A1 or B red blood cells also produce high titer antibodies to sheep red blood cells. Sheep red blood cells appear to possess AB-like as well as non-AB determinants on their surface membranes, each capable of producing and reacting with antibodies of their respective specificities. The antibodies against AB-like determinants preferentially agglutinate A or B cells whereas non-AB-like determinants preferentially stimulate hemolytic antibodies. Human antibodies reacting with these two kinds of determinants on sheep red blood cells may be produced in response to microorganisms possessing very similar factors on their membranes. Individuals who possess AB-like determinants in their secretions, similar to the determinants present on sheep red blood cells (or microorganisms), often make weaker antibodies to these red blood cells. Subjects lacking corresponding anti-sheep inhibitors in their secretions generally produce stronger sheep red blood cell antibodies. There is a positive correlation between the formation of antibodies to HBsAg and strong agglutinating antibodies to sheep red blood cells, indicating that similar determinants may be found on HBsAg virus and on sheep red blood cells. No such correlation was found for anti-tetanus antibodies.
A、B、O血型个体若产生针对A1或B型红细胞的免疫抗体，也会产生高效价的抗绵羊红细胞抗体。绵羊红细胞表面膜上似乎同时具有AB样和非AB决定簇，每种决定簇都能产生与其各自特异性抗体反应的抗体。针对AB样决定簇的抗体优先凝集A型或B型细胞，而非AB样决定簇则优先刺激溶血抗体。与绵羊红细胞上这两种决定簇反应的人类抗体，可能是因微生物膜上具有非常相似的因子而产生。其分泌物中含有与绵羊红细胞（或微生物）上存在的决定簇相似的AB样决定簇的个体，通常对这些红细胞产生较弱的抗体。分泌物中缺乏相应抗绵羊抑制剂的个体，一般会产生较强的绵羊红细胞抗体。抗HBsAg抗体的形成与高效价抗绵羊红细胞凝集抗体之间存在正相关，表明在HBsAg病毒和绵羊红细胞上可能存在相似的决定簇。而抗破伤风抗体则未发现这种相关性。
