Ansfield M J, Benson B J, Kaltreider H B
Am Rev Respir Dis. 1979 Oct;120(4):949-52. doi: 10.1164/arrd.1979.120.4.949.
Surface-active material isolated from the lungs of both dogs and rats was tested for its ability to suppress the in vitro proliferative responses of dog, mouse, or human lymphocytes to a variety of immunologic stimuli. Both dog and rat surface-active material exerted a dose-dependent suppressive effect on the proliferative responses of each species of lymphocyte, regardless of the nature of the immune stimulus (mitogen, antigen, or alloantigen). The data indicated that surface-active material acts by directly inhibiting the responding lymphocyte and not by activating suppessor cells. The immunosuppression could not be attributed to lymphocyte cytotoxicity. Although the mechanism of this immunosuppressive action of surface-active material remains undefined, the present data clearly indicate that such activity is not species specific.
从狗和大鼠的肺中分离出的表面活性物质，对其抑制狗、小鼠或人淋巴细胞对多种免疫刺激的体外增殖反应的能力进行了测试。无论免疫刺激的性质（促细胞分裂剂、抗原或同种异体抗原）如何，狗和大鼠的表面活性物质均对每种淋巴细胞的增殖反应产生剂量依赖性抑制作用。数据表明，表面活性物质通过直接抑制反应性淋巴细胞起作用，而不是通过激活抑制细胞。免疫抑制不能归因于淋巴细胞的细胞毒性。虽然表面活性物质这种免疫抑制作用的机制尚不清楚，但目前的数据清楚地表明，这种活性不是物种特异性的。
