Barnikol W K, Diether K
Arzneimittelforschung. 1979;29(10):1642-4.
Carboanhydrase inhibitors are said to have a positive effect on respiratory insufficiency. We examined this, especially regarding the bronchial system. Actions and reactions of the human bronchial system can be followed by measurement of the anatomical dead space breath by breath. We have developed a new method which was tested by classical broncho-effective substances. Our experiments show in case of two men with healthy lungs that the three carboanhydrase inhibitors acetazolamide, methazolamide, and dichlorphenamide have a pronounced broncholytic effect. The effect is greater than that of fenoterol. In addition the bronchial peristalsis and the bronchial compliance are increased. In contrast to fenoterol carboanhydrase inhibitors have no cardiac side effect.
碳酸酐酶抑制剂据说对呼吸功能不全有积极作用。我们对此进行了研究，尤其关注支气管系统。通过逐次测量解剖无效腔，能够追踪人体支气管系统的作用和反应。我们研发了一种新方法，并通过经典的支气管活性物质进行了测试。我们的实验表明，对于两名肺部健康的男性，三种碳酸酐酶抑制剂乙酰唑胺、甲醋唑胺和二氯非那胺具有显著的支气管舒张作用。其效果比非诺特罗更强。此外，支气管蠕动和支气管顺应性也有所增加。与非诺特罗不同，碳酸酐酶抑制剂没有心脏副作用。
