Wall J R, Walters B A, Grant C
J Endocrinol Invest. 1979 Oct-Dec;2(4):375-8. doi: 10.1007/BF03349336.
Leukocyte adherence inhibition (LAI) may be a test for cell-mediated immunity or cytophilic antibodies. LAI tests were carried out on patients with Graves' ophthalmopathy, using normal human lacrimal gland, orbital fat, and eye muscle extracts as antigens. The results were expressed as % LAI. The percentage leukocyte adherence inhibition in tests from patients and normal subjects were not significantly different for any preparation (Mann-Whitney tests). Taking the upper limit of normal as the mean % LAI + 2SD for normal subjects, tests were positive, to eye muscle extract, in only one patient whilst borderline inhibition, in response to eye muscle and fat extracts respectively, was demonstrated in two patients. All three had active disease. LAI tests may be positive only during the acute stage of Graves' ophthalmopathy. The significance of these findings in respect to the pathogenesis of Graves' ophthalmopathy is discussed.
白细胞黏附抑制（LAI）可能是一种检测细胞介导免疫或亲细胞抗体的方法。使用正常人泪腺、眼眶脂肪和眼肌提取物作为抗原，对格雷夫斯眼病患者进行了LAI检测。结果以LAI百分比表示。对于任何一种制剂，患者和正常受试者检测中的白细胞黏附抑制百分比均无显著差异（曼-惠特尼检验）。以正常上限作为正常受试者的平均LAI百分比+2标准差，仅1例患者对眼肌提取物检测呈阳性，2例患者分别对眼肌和脂肪提取物呈临界抑制。这3例患者均患有活动性疾病。LAI检测可能仅在格雷夫斯眼病的急性期呈阳性。本文讨论了这些发现对于格雷夫斯眼病发病机制的意义。
