Parent R A
Drug Chem Toxicol. 1979;2(4):369-74. doi: 10.3109/01480547909016030.
Thrice weekly application of lambda-mercapto-polydimethylsiloxane to the shaven backs of Swiss mice over an 18 month period did not have an obvious effect on weight gain nor did this material produce systemic toxicity. Lung adenomas and lymphosarcomas were observed upon histopathological examination in both untreated and treated group. Other lesions observed were not thought to be treatment related.
在18个月的时间里，每周三次将λ-巯基聚二甲基硅氧烷涂抹于剃毛的瑞士小鼠背部，对体重增加没有明显影响，该物质也未产生全身毒性。在组织病理学检查中，未处理组和处理组均观察到肺腺瘤和淋巴肉瘤。观察到的其他病变被认为与治疗无关。
