妊娠巨幼细胞贫血时红细胞中叶酸活性的酶促释放
Enzymatic release of folate activity from the red cells in megaloblastic anaemia of pregnancy.
作者信息
Grzesiukowicz H, Jennison R F, Gowenlock A H
出版信息
J Clin Pathol. 1965 Sep;18(5):599-604. doi: 10.1136/jcp.18.5.599.
The content of folate activity precursors in washed red cells and the enzymatic plasma factor activity, necessary for the release of folate from the precursors, were studied in normal subjects and in patients with megaloblastic anaemia of pregnancy. Subjects with megaloblastic anaemia of pregnancy had a significantly reduced folate activity precursor content, and 14 subjects (58%) had significantly low plasma factor activity, which in at least four subjects may have been due to the presence of inhibitors. This study indicates that impaired activity of the plasma factor may play a part in the aetiology of megaloblastic anaemia of pregnancy.
对正常受试者以及妊娠巨幼细胞贫血患者的洗涤红细胞中叶酸活性前体的含量，以及从前体中释放叶酸所必需的血浆酶因子活性进行了研究。妊娠巨幼细胞贫血患者的叶酸活性前体含量显著降低，14名受试者（58%）的血浆因子活性显著偏低，其中至少有4名受试者的这种情况可能是由于存在抑制剂。这项研究表明，血浆因子活性受损可能在妊娠巨幼细胞贫血的病因中起作用。
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