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相似文献

1
Release of formaldehyde from polynoxylin and noxythiolin.聚维酮碘和硝噻唑啉中甲醛的释放。
J Clin Pathol. 1965 Sep;18(5):666-7. doi: 10.1136/jcp.18.5.666.
2
Stability of noxythiolin solutions stored in plastic and glass containers.
J Clin Hosp Pharm. 1984 Sep;9(3):241-7. doi: 10.1111/j.1365-2710.1984.tb01082.x.
3
Mechanisms of antibacterial formaldehyde delivery from noxythiolin and other 'masked-formaldehyde' compounds.来自硝噻啉及其他“掩蔽甲醛”化合物的抗菌性甲醛释放机制。
J Pharm Pharmacol. 1983 Nov;35(11):712-7. doi: 10.1111/j.2042-7158.1983.tb02876.x.
4
Anaflex and noxyflex: low-toxicity antiseptics.Anaflex和Noxyflex：低毒性防腐剂。
Drug Ther Bull. 1970 Oct 23;8(20):79-80.
5
A comparison of the antimicrobial activities of noxythiolin and formaldehyde solutions.诺西硫脲与甲醛溶液抗菌活性的比较。
J Clin Hosp Pharm. 1985 Jun;10(2):185-92. doi: 10.1111/j.1365-2710.1985.tb01132.x.
6
Biological activity of polynoxylin--an insoluble urea-formaldehyde condensation product.聚诺昔林的生物活性——一种不溶性脲醛缩合产物
J Clin Hosp Pharm. 1985 Dec;10(4):367-72. doi: 10.1111/j.1365-2710.1985.tb00935.x.
7
Sustained anti-adherence activity of taurolidine (Taurolin) and noxythiolin (Noxyflex S) solutions.
J Pharm Pharmacol. 1988 Jul;40(7):509-11. doi: 10.1111/j.2042-7158.1988.tb05288.x.
8
Differential pulse polarographic determination of formaldehyde in stored noxythiolin solutions.微分脉冲极谱法测定储存的诺西肽溶液中的甲醛
J Clin Hosp Pharm. 1985 Jun;10(2):177-83. doi: 10.1111/j.1365-2710.1985.tb01131.x.
9
Inhibition of hyphal development and kill of Candida albicans blastospores by noxythiolin in vitro.诺西硫脲在体外对白色念珠菌菌丝发育的抑制及对芽生孢子的杀伤作用
J Appl Bacteriol. 1986 Apr;60(4):319-25. doi: 10.1111/j.1365-2672.1986.tb01739.x.
10
Noxythiolin--high-performance liquid chromatographic assay and stability.诺昔硫脲——高效液相色谱分析法及稳定性
J Clin Hosp Pharm. 1984 Mar;9(1):41-51. doi: 10.1111/j.1365-2710.1984.tb00917.x.

引用本文的文献

1
Microbiological studies on some bladder irrigation fluids.关于某些膀胱冲洗液的微生物学研究。
Infection. 1976;4(2):31-4. doi: 10.1007/BF01638345.

本文引用的文献

1
POLYOXYMETHYLENEUREA IN OTOLOGY.聚氧化亚甲基脲在耳科学中的应用
Lancet. 1963 Dec 28;2(7322):1348-50. doi: 10.1016/s0140-6736(63)90735-9.
2
Self-disinfecting surface coatings which evolve formaldehyde.可释放甲醛的自消毒表面涂层。
Mon Bull Minist Health Public Health Lab Serv. 1962 Dec;21:246-51.
3
Polynoxylin (Anaflex) in dermatology.聚氧乙烯（Anaflex）在皮肤科的应用。
Br J Dermatol. 1962 Oct;74:364-71.
4
A misapplication of the sensitivity test. Mandelamine discs.敏感性试验的错误应用。乌洛托品药敏纸片。
J Med Lab Technol. 1962 Jul;19:163-8.
5
Polynoxylin.聚氧西林
Nature. 1963 Apr 27;198:400-1. doi: 10.1038/198400b0.
6
A new, highly effective but non-toxic antibacterial substance.一种新型的、高效但无毒的抗菌物质。
Nature. 1961 May 20;190:734-5. doi: 10.1038/190734a0.
7
The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.通过汉茨希反应对比色法测定甲醛。
Biochem J. 1953 Oct;55(3):416-21. doi: 10.1042/bj0550416.

聚维酮碘和硝噻唑啉中甲醛的释放。

Release of formaldehyde from polynoxylin and noxythiolin.

作者信息

Kingston D

出版信息

J Clin Pathol. 1965 Sep;18(5):666-7. doi: 10.1136/jcp.18.5.666.

DOI:10.1136/jcp.18.5.666
PMID:5835451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC473043/
Abstract

Polynoxylin and noxythiolin (Anaflex and Noxyflex) have been recommended for the treatment of certain bacterial infections. Both compounds were shown to release formaldehyde. Detailed studies with noxythiolin showed that it decomposed in solution to liberate most of its formaldehyde, and that solutions of formaldehyde of the appropriate strength gave zones of inhibition on seeded plates comparable in size with those given by noxythiolin. It is suggested that the effects observed with these compounds are caused by the formaldehyde released.

摘要

聚羟甲酚和硝羟喹啉（Anaflex和Noxyflex）已被推荐用于治疗某些细菌感染。这两种化合物都被证明会释放甲醛。对硝羟喹啉的详细研究表明，它在溶液中分解以释放大部分甲醛，并且适当强度的甲醛溶液在接种平板上产生的抑菌圈大小与硝羟喹啉产生的抑菌圈相当。有人认为，观察到的这些化合物的作用是由释放的甲醛引起的。