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人血清中的石胆酸。

Lithocholic acid in human-blood serum.

作者信息

Carey J B, Williams G

出版信息

Science. 1965 Oct 29;150(3696):620-2. doi: 10.1126/science.150.3696.620.

DOI:10.1126/science.150.3696.620
PMID:5837102
Abstract

Lithocholic acid was present in the serum of three patients with, jaundice and, in smaller amounts, in two healthy adults. This bile acid occurs naturally in human feces but induces cirrhosis of the liver when fed to a wide variety of experimental animals. The finding of lithocholic acid in blood is of interest because of its possible role in injuring human liver.

摘要

在三名黄疸患者的血清中发现了石胆酸,在两名健康成年人的血清中也发现了少量石胆酸。这种胆汁酸天然存在于人类粪便中,但当喂食给多种实验动物时会诱发肝硬化。血液中发现石胆酸很有意思,因为它可能对人类肝脏造成损伤。

相似文献

1
Lithocholic acid in human-blood serum.人血清中的石胆酸。
Science. 1965 Oct 29;150(3696):620-2. doi: 10.1126/science.150.3696.620.
2
Occurrence of lithocholic acid in feces of healthy men.健康男性粪便中石胆酸的存在情况。
Science. 1958 Dec 5;128(3336):1433-4. doi: 10.1126/science.128.3336.1433.
3
[Bile acid metabolism in hepatic tissue of healthy subjects and in patients with liver cirrhosis].[健康受试者及肝硬化患者肝脏组织中的胆汁酸代谢]
Z Gastroenterol. 1973 Apr;11(3):203-16.
4
The effect of cholesterol feeding on gallbladder bile acids of the rabbit. Evidence that lithocholic acid is a primary bile acid in the rabbit.胆固醇喂养对兔胆囊胆汁酸的影响。证明石胆酸是兔的一种初级胆汁酸。
Biochem J. 1981 Sep 15;198(3):639-43. doi: 10.1042/bj1980639.
5
METABOLITES OF LITHOCHOLIC ACID-24-C-14 IN HUMAN BILE AND FECES.人胆汁和粪便中石胆酸-24-C-14的代谢产物
J Lab Clin Med. 1964 Jun;63:986-1001.
6
Binding of bile acids by 100 000g supernatants from rat liver.大鼠肝脏100000g上清液对胆汁酸的结合作用。
Biochem J. 1977 Mar 15;162(3):659-64. doi: 10.1042/bj1620659.
7
Unsaturated monohydroxy bile acids in cholestatic liver disease.胆汁淤积性肝病中的不饱和单羟基胆汁酸
Biochem J. 1972 Sep;129(2):491-4. doi: 10.1042/bj1290491.
8
Sulfation and renal excretion of bile salts in patients with cirrhosis of the liver.肝硬化患者胆汁盐的硫酸化作用及经肾排泄情况
Gastroenterology. 1975 Mar;68(3):534-44.
9
Metabolism and effect of 7-oxo-lithocholic acid 3-sulfate on bile flow and biliary lipid secretion in rats.7-氧代石胆酸3-硫酸盐对大鼠胆汁流量和胆汁脂质分泌的代谢及影响
Hepatology. 1994 Sep;20(3):663-71.
10
Bile acid metabolism during development: metabolism of lithocholic acid in human fetal liver.
Pediatr Res. 1987 Jan;21(1):99-103. doi: 10.1203/00006450-198701000-00021.

引用本文的文献

1
Inflammatory pseudo-tumor of the liver: a rare pathological entity.肝脏炎性假瘤:一种罕见的病理实体。
World J Surg Oncol. 2011 Jan 23;9:5. doi: 10.1186/1477-7819-9-5.
2
Production of bile duct hyperplasia and gallstones by lithocholic acid.石胆酸导致胆管增生和胆结石的形成。
J Clin Invest. 1966 Aug;45(8):1255-67. doi: 10.1172/JCI105432.
3
Anemia with spur cells: a red cell defect acquired in serum and modified in the circulation.伴有棘形红细胞的贫血:一种在血清中获得并在循环中发生改变的红细胞缺陷。
J Clin Invest. 1969 Oct;48(10):1820-31. doi: 10.1172/JCI106148.
4
Serum bile acids in primary biliary cirrhosis.原发性胆汁性肝硬化中的血清胆汁酸
Gut. 1972 Mar;13(3):201-6. doi: 10.1136/gut.13.3.201.
5
An analysis of lipoproteins, bile acids, and red cell membranes associated with target cells and spur cells in patients with liver disease.对肝病患者中与靶细胞和棘状细胞相关的脂蛋白、胆汁酸及红细胞膜的分析。
J Clin Invest. 1972 Dec;51(12):3182-92. doi: 10.1172/JCI107145.
6
Identification of bile acids in the serum and urine in cholestasis. Evidence for 6alpha-hydroxylation of bile acids in man.胆汁淤积时血清和尿液中胆汁酸的鉴定。人类胆汁酸6α-羟基化的证据。
Biochem J. 1976 Feb 15;154(2):507-16. doi: 10.1042/bj1540507.