同源甲状腺提取物不同组分在大鼠过敏性甲状腺炎产生中的活性。
The activity of different fractions of homologous thyroid extract in the production of allergic thyroiditis in the rat.
作者信息
Roitt I M, Jones H E, Mills G L
出版信息
Immunology. 1965 Sep;9(3):281-6.
Abstract
Rat thyroglobulin with a high degree of ultracentrifugal purity can be obtained by zone ultracentrifugation of crude thyroid extracts. The thyroglobulin fraction was even more effective than the original extract as an antigen for the production of experimental allergic thyroiditis. Material in the extracts with lower sedimentation coefficients than thyroglobulin were ineffective as antigens in this respect as was a homologous thyroid microsomal fraction.
摘要
通过对粗甲状腺提取物进行区带超速离心，可以获得具有高度超速离心纯度的大鼠甲状腺球蛋白。甲状腺球蛋白组分作为实验性过敏性甲状腺炎的抗原，其效果甚至比原始提取物更好。提取物中沉降系数低于甲状腺球蛋白的物质，以及同源甲状腺微粒体组分，在这方面作为抗原均无效。
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