甲状腺抗原对桥本甲状腺炎患者白细胞体外迁移的影响。
The effect of thyroid antigens on the in vitro migration of leucocytes from patients with Hashimoto thyroiditis.
作者信息
Calder E A, McLeman D, Barnes E W, Irvine W J
出版信息
Clin Exp Immunol. 1972 Dec;12(4):429-38.
Abstract
A total of fifty-two patients with Hashimoto thyroiditis were tested for delayed hypersensitivity to thyroid antigens using the leucocyte migration test. The percentage of patients showing abnormal migration in the presence of crude thyroid extract, thyroglobulin, thyroid mitochondria and thyroid microsomes was 75, 44, 54 and 34% respectively. Fifty-three control patients were studied concurrently with the same antigens and the percentage showing abnormal migration was 4, 6, 6 and 6% respectively. The antigenic activity of the mitochondrial fraction was not organ specific; both liver and kidney mitochondria interfered with the migration of leucocytes from patients with Hashimoto thyroiditis.
摘要
共有52例桥本甲状腺炎患者采用白细胞迁移试验检测对甲状腺抗原的迟发型超敏反应。在存在粗甲状腺提取物、甲状腺球蛋白、甲状腺线粒体和甲状腺微粒体的情况下，显示迁移异常的患者百分比分别为75%、44%、54%和34%。同时对53例对照患者使用相同抗原进行研究，显示迁移异常的百分比分别为4%、6%、6%和6%。线粒体部分的抗原活性并非器官特异性的；肝和肾线粒体均会干扰桥本甲状腺炎患者白细胞的迁移。
相似文献
1
The effect of thyroid antigens on the in vitro migration of leucocytes from patients with Hashimoto thyroiditis.
Clin Exp Immunol. 1972 Dec;12(4):429-38.
2
Leucocyte migration inhibition with mitochondria in human autoimmune thyroid disorders.
Clin Exp Immunol. 1973 Jun;14(2):203-12.
3
Leucocyte migration inhibition in thyroid disease. Effect of human thyroid microsomes and thyroglobulin.
Int Arch Allergy Appl Immunol. 1973;44(3):396-408. doi: 10.1159/000230947.
4
Cellular hypersensitivity in Hashimoto's thyroiditis. Specific action of thyroid extract upon the migration of leucocytes in vitro.
Acta Med Scand. 1968 Jan-Feb;183(1-2):101-5.
5
The effect of gastric antigens on the in vitro migration of leucocytes from patients with atrophic gastritis and pernicious anaemia.
Clin Exp Immunol. 1973 Aug;14(4):501-8.
6
[Antigens of normal and pathologically changed human thyroid gland].
Sov Med. 1970 Sep;33(9):125-31.
7
[Antithyroid antibodies during autoimmune thyroiditis: technique comparison].
Ann Biol Clin (Paris). 1997 Nov-Dec;55(6):614-8.
8
[Clinical studies on chronic thyroiditis with reference to thyroid antibodies in the blood].
Nihon Naibunpi Gakkai Zasshi. 1967 Dec 20;43(9):884-95. doi: 10.1507/endocrine1927.43.9_884.
9
[Studies on "cellular antibodies" against thyroid gland antigens in immunothyroiditis and hyperthyroidism].
Verh Dtsch Ges Inn Med. 1971;77:1129-33.
10
HLA in primary atrophic hypothyroidism and Hashimoto goitre.
J Clin Lab Immunol. 1978 Nov;1(3):193-5.
引用本文的文献
1
Autoimmunity in endocrine disease.
Proc R Soc Med. 1974 Jun;67(6 Pt 2):548-56. doi: 10.1177/00359157740676P207.
2
Relationship of age-specific incidence rates to immunological aspects of Hashimoto's thyroiditis.
Can Med Assoc J. 1973 Nov 3;109(9):898-901.
3
Increase of peripheral B lymphocytes in Graves' disease.
Clin Exp Immunol. 1980 Oct;42(1):33-40.
4
Thyroid transplantation developing autoimmune thyroiditis following thymectomy and irradiation.
Clin Exp Immunol. 1981 Sep;45(3):480-6.
5
Leukocyte migration test (LMT) in patients with thyroid disease: the response to human thyroid subcellular fractions.
J Endocrinol Invest. 1981 Apr-Jun;4(2):173-6. doi: 10.1007/BF03350447.
6
Leucocyte migration studies in Crohn's disease using Crohn's colon homogenate and mitochondrial and microsomal fractions.
Gut. 1974 Jan;15(1):19-23. doi: 10.1136/gut.15.1.19.
7
The effect of gastric antigens on the in vitro migration of leucocytes from patients with atrophic gastritis and pernicious anaemia.
Clin Exp Immunol. 1973 Aug;14(4):501-8.
8
Leucocyte migration inhibition with mitochondria in human autoimmune thyroid disorders.
Clin Exp Immunol. 1973 Jun;14(2):203-12.
9
Cytotoxic lymphocytes in Hashimoto thyroiditis. An in vitro assay system using 51 Cr-labelled chicken red blood cells coated with thyroglobulin.
Clin Exp Immunol. 1973 May;14(1):19-23.
10
Cell-mediated immunity in diabetes mellitus.
Proc R Soc Med. 1974 Jun;67(6 Pt 1):506-13. doi: 10.1177/00359157740676P135.
本文引用的文献
1
Human autoimmune thyroiditis: serological studies.
Lancet. 1958 Nov 15;2(7055):1027-33. doi: 10.1016/s0140-6736(58)90530-0.
2
Precipitin tests in thyroid disease.
Lancet. 1957 Nov 16;273(7003):976-9. doi: 10.1016/s0140-6736(57)92002-0.
3
The transfer of allergic thyroiditis in histocompatible guinea pigs by lymph node cells.
J Immunol. 1967 Jul;99(1):208-13.
4
Cellular and humoral immune responses in experimental autoimmune thyroiditis.
Int Arch Allergy Appl Immunol. 1971;40(6):917-27. doi: 10.1159/000230473.
5
In-vitro inhibition of leucocyte migration in Crohn's disease by a sarcoid spleen suspension.
Br Med J. 1971 Jul 17;3(5767):155-7. doi: 10.1136/bmj.3.5767.155.
6
Transfer of experimental autoimmune thyroiditis of the mouse by serum.
J Immunol. 1971 Apr;106(4):1139-42.
7
Migration inhibition studies in human disease.
Proc R Soc Med. 1970 Sep;63(9):905-6. doi: 10.1177/003591577006300919.
8
A leucocyte migration technique for in vitro detection of cellular (delayed type) hypersensitivity in man.
Dan Med Bull. 1969 Jan;16(1):1-6.
9
Anti-adrenal, cellular hypersensitivity in Addison's disease.
Clin Exp Immunol. 1969 Apr;4(4):355-63.
10
Cellular hypersensitivity in Hashimoto's thyroiditis. Specific action of thyroid extract upon the migration of leucocytes in vitro.
Acta Med Scand. 1968 Jan-Feb;183(1-2):101-5.
Zotero 插件