Richmond A S, Simberkoff M S, Schaefler S, Rahal J J
J Infect Dis. 1977 Jan;135(1):108-12. doi: 10.1093/infdis/135.1.108.
Six strains of Staphylococcus aureus resistant to semisynthetic penicillins were recovered from clinical sources during a two-month period. Resistance was detected by standard disk sensitivity tests at 37 C. Two resistant strains were responsible for infections (one of which was fatal), and five strains were susceptible only to phage type 92. All of the strains produced penicillinase, which did not destroy oxacillin, and each was resistant to oxacillin at low inocula. Relative resistance to cephalosporin was demonstrable by the tube dilution assay but not by standard disk tests. The strains susceptible to phage type 92 were susceptible to vancomycin and to the synergistic action of oxacillin or cephalothin plus gentamicin.
在两个月的时间里，从临床样本中分离出了6株对半合成青霉素耐药的金黄色葡萄球菌。通过在37℃下进行标准纸片药敏试验检测耐药性。其中两株耐药菌株引发了感染（其中一例导致死亡），另外五株仅对92型噬菌体敏感。所有菌株均产生青霉素酶，但该酶不会破坏苯唑西林，并且每株在低接种量时对苯唑西林耐药。通过试管稀释法可证明对头孢菌素的相对耐药性，但标准纸片试验无法检测到。对92型噬菌体敏感的菌株对万古霉素以及苯唑西林或头孢噻吩与庆大霉素的协同作用敏感。
