Koistinen J, Heikkilä M, Leikola J
Br Med J. 1978 Sep 30;2(6142):923-4. doi: 10.1136/bmj.2.6142.923.
Antibodies to IgA may cause severe anaphylactic reactions during blood transfusions. Tests for anti-IgA antibodies were carried out on six patients with IgA deficiency (five of whom also had hypogammaglobulinaemia) who had received continuous gammaglobullin treatment for chronic or recurrent infections for three to eight years. Three patients had minute amounts of IgA, and three had none (less than 0.01 microgram/ml). Only one patient had anti-IgA. Her antibody titre did not change during treatment. No patient had any untoward effects of treatment, which relieved the symptoms of infection in every case. IgA determinations should be performed by more accurate methods than radial immunodiffusion when evaluating the risks of giving gammaglobulin to patients with hypogammaglobulinaemia and IgA deficiency. Probably the stimulus provided by intramuscular gammaglobulin in such patients is insufficient for the formation of anti-IgA antibody.
抗IgA抗体可能会在输血过程中引发严重的过敏反应。对6名患有IgA缺乏症（其中5名还患有低丙种球蛋白血症）的患者进行了抗IgA抗体检测，这些患者因慢性或复发性感染接受了3至8年的持续丙种球蛋白治疗。3名患者有微量IgA，3名患者没有（低于0.01微克/毫升）。只有1名患者有抗IgA。她的抗体滴度在治疗期间没有变化。没有患者出现任何治疗不良反应，而且在每种情况下治疗都缓解了感染症状。在评估给低丙种球蛋白血症和IgA缺乏症患者输注丙种球蛋白的风险时，IgA测定应采用比放射免疫扩散更准确的方法。肌肉注射丙种球蛋白对此类患者提供的刺激可能不足以形成抗IgA抗体。
