Brazzuna H, García Pierce H, Libermann I M
Acta Physiol Lat Am. 1975;25(2):83-8.
To study the variations of blood constituents during water deprivation, rats were deprived of water from six to twelve days. Control and rehydrated animals were also included in the study. A significant increase was observed in sodium, chloride and hematocrit throughout the experiment. Calcium, bicarbonate and PCO2 increased at 10-11 days of treatment. Potassium, inorganic phosphorus, pH, base excess and blood buffer capacity did not change in the course of the experiment. Rehydrated animals recovered to control levels in all the studied components, except for pH and base excess, which increased somewhat. Plasma volume changes could explain only partially electrolyte variation. The "dehydration reaction" is considered to be the main mechanism responsible for these changes. Unchanged hematocrit levels in water deprived animals suggest that after 6 days of water deprivation there is no further loss of plasma water. Bicarbonate and PCO2 changes showed a good relationship and may account for unchanged pH and base excess values.
为研究禁水期间血液成分的变化，将大鼠禁水6至12天。研究中还纳入了对照动物和再水化动物。在整个实验过程中，观察到钠、氯和血细胞比容显著增加。在治疗的第10至11天，钙、碳酸氢盐和PCO2增加。钾、无机磷、pH、碱剩余和血液缓冲能力在实验过程中未发生变化。再水化动物除pH和碱剩余略有增加外，所有研究成分均恢复到对照水平。血浆容量变化只能部分解释电解质变化。“脱水反应”被认为是导致这些变化的主要机制。禁水动物血细胞比容水平未变，表明禁水6天后血浆水不再进一步丢失。碳酸氢盐和PCO2的变化显示出良好的相关性，可能解释了pH和碱剩余值未变的原因。
