Moore D H, Arison R N, Tanaka H, Hall W T, Chanowitz M
J Bacteriol. 1965 Dec;90(6):1669-74. doi: 10.1128/jb.90.6.1669-1674.1965.
Moore, D. H. (The Rockefeller University, New York, N. Y.), R. N. Arison, H. Tanaka, W. T. Hall, and M. Chanowitz. Identity of the filterable hemolytic anemia agent of Sacks with Haemobartonella muris. J. Bacteriol. 90:1669-1674. 1965.-In 1960 a new hemolytic agent in rats was reported. It was thought to be a filterable, nonsedimentable, replicating infectious agent, different from Haemobartonella muris. Rats which recovered from the infection developed a resistance to several kinds of transplantable tumors. It is here shown that this agent has the same properties as those reported in the literature and reconfirmed by us for H. muris. The size of the agent is approximately 500 mmu as determined by correlating bioactivity with Gradocol membrane filtrates and fractions from a diffusion cell, and its density is about midway between that of whole serum and distilled water (approximately 1.020) as determined by the sedimentation of bioactivity in an ultracentrifuge. Diffusion at 30 C indicated a lack of motility by the agent bodies. Rats were found to be protected against infection with the agent by daily administration of chlortetracycline and by prior infection with H. muris. The agent bodies were indistinguishable from H. muris in both the light and the electron microscope.
摩尔，D. H.（纽约洛克菲勒大学），R. N. 阿里森，H. 田中，W. T. 霍尔，以及M. 查诺维茨。萨克斯氏可滤过性溶血性贫血病原体与鼠血巴尔通体的同一性。《细菌学杂志》90:1669 - 1674。1965年。——1960年报道了一种大鼠体内的新型溶血因子。它被认为是一种可滤过、不可沉淀、能复制的感染因子，与鼠血巴尔通体不同。从感染中恢复的大鼠对几种可移植肿瘤产生了抗性。本文表明，该因子具有文献中报道的且经我们再次确认的鼠血巴尔通体的相同特性。通过将生物活性与格拉多科尔膜滤液以及扩散池中的组分相关联来确定，该因子的大小约为500毫微米，通过在超速离心机中生物活性的沉降来确定，其密度约在全血清和蒸馏水之间（约1.020）。在30℃下的扩散表明该因子体缺乏运动性。发现通过每日给予金霉素以及预先感染鼠血巴尔通体可保护大鼠免受该因子的感染。在光学显微镜和电子显微镜下，该因子体与鼠血巴尔通体无法区分。
