乙酰肉碱对线粒体脂肪酸和乙酸氧化的刺激作用。
Stimulation of oxidation of mitochondrial fatty acids and of acetate by acetylcarnitine.
作者信息
Siliprandi N, Siliprandi D, Ciman M
出版信息
Biochem J. 1965 Sep;96(3):777-80. doi: 10.1042/bj0960777.
Abstract
- Acetylcarnitine added in catalytic amounts to kidney mitochondria produces an active oxidation of endogenous fatty acids. 2. In conditions of mitochondrial ;aging', under which acetate is not oxidized, acetylcarnitine also promotes the oxidation of this exogenous substrate. 3. Dinitrophenol completely abolishes the action of acetylcarnitine. 4. Carnitine is ineffective both in the oxidation of endogenous fatty acids and of exogenous acetate. 5. The action of acetylcarnitine is shared, though to a smaller extent, by pyruvate. 6. The mechanism of acetylcarnitine action has been interpreted by considering that the readily oxidizable acetyl group of acetylcarnitine can supply the initial investment of energy needed to start fatty acid oxidation.
摘要
- 向肾线粒体中添加催化量的乙酰肉碱会使内源性脂肪酸发生活跃氧化。2. 在线粒体“老化”的情况下，此时乙酸盐无法被氧化，乙酰肉碱也能促进这种外源性底物的氧化。3. 二硝基苯酚完全消除了乙酰肉碱的作用。4. 肉碱对内源性脂肪酸和外源性乙酸盐的氧化均无作用。5. 丙酮酸也具有乙酰肉碱的作用，不过程度较小。6. 乙酰肉碱的作用机制被解释为，乙酰肉碱中易于氧化的乙酰基团能够提供启动脂肪酸氧化所需的初始能量投入。
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