大鼠发育过程中的肉碱与棕色脂肪组织代谢
Carnitine and brown adipose tissue metabolism in the rat during development.
作者信息
Hahn P, Skala J
出版信息
Biochem J. 1972 Mar;127(1):107-11. doi: 10.1042/bj1270107.
Abstract
- The content of carnitine, acylcarnitine and total acid soluble carnitine in brown adipose tissue of rats increases rapidly after birth, attaining a peak on about day 10 and then decreases. Similar changes with age were found for carnitine acetyltransferase activity in mitochondria from brown adipose tissue and heart. The activity of this enzyme in brain and in liver is much smaller, but also increases postnatally. 2. The activity of carnitine palmitoyltransferase in brown adipose tissue, however, decreases after birth then increases later in life. 3. Exposure of 18-day-old rats to the cold for 20 days leads to an increase in carnitine content in brown adipose tissue and raises the activity of carnitine acetyltransferase. The activity of carnitine palmitoyltransferase is not affected by cold adaptation.
摘要
- 大鼠棕色脂肪组织中肉碱、酰基肉碱和总酸溶性肉碱的含量在出生后迅速增加，在大约第10天达到峰值，然后下降。棕色脂肪组织和心脏线粒体中的肉碱乙酰转移酶活性也发现了随年龄的类似变化。该酶在脑和肝脏中的活性要小得多，但在出生后也会增加。2. 然而，棕色脂肪组织中肉碱棕榈酰转移酶的活性在出生后下降，随后在生命后期增加。3. 18日龄大鼠暴露于寒冷环境20天会导致棕色脂肪组织中肉碱含量增加，并提高肉碱乙酰转移酶的活性。肉碱棕榈酰转移酶的活性不受冷适应的影响。
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本文引用的文献
1
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Biochem J. 1967 Dec;105(3):953-63. doi: 10.1042/bj1050953.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
THE EFFECT OF CARNITINE ON THE RATE OF INCORPORATION OF PRECURSORS INTO FATTY ACIDS.肉碱对前体掺入脂肪酸速率的影响。
J Biol Chem. 1965 Feb;240:622-7.
4
PALMITYL-COA:CARNITINE PALMITYLTRANSFERASE. PURIFICATION FROM CALF-LIVER MITOCHONDRIA AND SOME PROPERTIES OF THE ENZYME.棕榈酰辅酶A：肉碱棕榈酰转移酶。从小牛肝脏线粒体中纯化及该酶的一些性质
Biochim Biophys Acta. 1964 Jul 8;89:95-108.
5
ENZYMOLOGICAL DETERMINATION OF FREE CARNITINE CONCENTRATIONS IN RAT TISSUES.大鼠组织中游离肉碱浓度的酶学测定
J Lipid Res. 1964 Apr;5:184-7.
6
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Am J Physiol. 1964 Mar;206:531-5. doi: 10.1152/ajplegacy.1964.206.3.531.
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J Biol Chem. 1966 Sep 10;241(17):4092-7.
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