控制针对变性锥虫DNA的IgM和IgG抗体反应的因素。
Factors controlling IgM and IgG antibody responses to denatured trypanosome DNA.
作者信息
Kushimo J B
出版信息
Immunology. 1976 May;30(5):635-9.
Rabbits immunized with complexes of denatured calf thymus DNA and methylated bovine serum albumin (MBSA) produced only IgM antibodies to denatured DNA, confirming the results of previous studies. In contrast, both IgM and IgG antibodies were induced by MBSA complexes of Trypanosoma brucei DNA. A similar response was observed by Gruenewald and Stollar (1973) to T2 bacteriophage DNA, in which the normal base cytosine is replaced by hydroxymethylcytosine. T2 bacteriophage DNA is known to have a high adenine+thymine (A + T) content. It is suggested that the 7S antibody response to MBSA complexes of T. brucei DNA might be linked to the high A + T content in the DNA (especially kinetoplast DNA) of the subgenus Trypanozoon.
用变性小牛胸腺DNA与甲基化牛血清白蛋白（MBSA）复合物免疫的兔子仅产生针对变性DNA的IgM抗体，这证实了先前研究的结果。相比之下，布氏锥虫DNA的MBSA复合物可诱导IgM和IgG抗体。Gruenewald和Stollar（1973年）观察到对T2噬菌体DNA有类似反应，其中正常碱基胞嘧啶被羟甲基胞嘧啶取代。已知T2噬菌体DNA具有高腺嘌呤+胸腺嘧啶（A + T）含量。有人提出，对布氏锥虫DNA的MBSA复合物的7S抗体反应可能与锥虫亚属DNA（特别是动质体DNA）中的高A + T含量有关。
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