B细胞激活中的抗原非特异性T细胞因子。起源、生物学特性以及与H-2无相关性的表现
Antigen-non-specific T-cell factor in B-cell activation. Origin, biological properties and failure to show a relationship to H-2.
作者信息
Waldmann H, Poulton P, Desaymard C
出版信息
Immunology. 1976 May;30(5):723-33.
Abstract
A population of T cells sensitive to ALS treatment release a non-specific factor (NSF) capable of replacing T cells in the response of nude spleen cells to erythrocyte antigens. This factor cannot be removed by immunoadsorbents with specificities directed towards products of the H2 complex, nor by lentil lectin, unlike certain specific T-cell factors. Furthermore, it functions across histocompatibility differences between mouse strains. It has been directly demonstrated that this factor can influence both proliferation and differentiation of B cells in response to a restricted group of T-dependent antigens, of which donkey and sheep erythrocytes are such special cases.
摘要
一群对ALS治疗敏感的T细胞释放出一种非特异性因子（NSF），该因子能够在裸脾细胞对红细胞抗原的反应中替代T细胞。与某些特异性T细胞因子不同，这种因子不能被针对H2复合体产物的免疫吸附剂去除，也不能被扁豆凝集素去除。此外，它在不同小鼠品系的组织相容性差异中发挥作用。已经直接证明，这种因子能够影响B细胞对一组受限的T依赖性抗原的增殖和分化，驴和绵羊红细胞就是这类特殊的T依赖性抗原。
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本文引用的文献
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Differential effects of human granulocytes and lymphocytes on human fibroblasts in vitro.人粒细胞和淋巴细胞在体外对人成纤维细胞的不同作用。
Clin Exp Immunol. 1968 Oct;3(8):817-36.
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Antigen-specific T-cell factor in cell cooperation: physical properties and mapping in the left-hand (K) half of H-2.细胞协作中的抗原特异性T细胞因子：物理性质及在H-2左手（K）半区的定位
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Separation of mouse spleen cells by passage through columns of sephadex G-10.通过葡聚糖凝胶G - 10柱对小鼠脾细胞进行分离。
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T cell factor which can replace T cells in vivo.可在体内替代T细胞的T细胞因子。
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Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
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Induction of antibody-forming cell clones in microcultures.微量培养中抗体形成细胞克隆的诱导。
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Activation of T and B lymphocytes in vitro. II. Biological and biochemical properties of an allogeneic effect factor (AEF) active in triggering specific B lymphocytes.体外T和B淋巴细胞的激活。II. 一种在触发特异性B淋巴细胞中起作用的同种异体效应因子（AEF）的生物学和生化特性。
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