初次免疫应答中的特异性细胞刺激：量化模型的实验测试
Specific cellular stimulation in the primary immune response: experimental test of a quantized model.
作者信息
Dintzis R Z, Vogelstein B, Dintzis H M
出版信息
Proc Natl Acad Sci U S A. 1982 Feb;79(3):884-8. doi: 10.1073/pnas.79.3.884.
Abstract
Dose-response and dose-suppression curves have been measured for the primary immune response in mice, in vivo and in vitro, by using size-fractionated linear polymers of acrylamide substituted with hapten. The results are in general agreement with a simple theory based on the premise that the specific primary immunological response is quantized at some fundamental and limiting step, requiring a minimum number of linked antigen receptors for response.
摘要
通过使用用半抗原取代的丙烯酰胺的尺寸分级线性聚合物，已在体内和体外测量了小鼠初次免疫反应的剂量反应和剂量抑制曲线。结果与基于特定初次免疫反应在某些基本和限制步骤中被量化这一前提的简单理论总体一致，该反应需要最少数量的连接抗原受体来产生反应。
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Generation of idiotype-specific T cell help through network perturbation.通过网络扰动产生独特型特异性T细胞辅助。
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Specific cellular stimulation in the primary immune response: a quantized model.初次免疫应答中的特异性细胞刺激：一种量化模型。
Proc Natl Acad Sci U S A. 1982 Jan;79(2):395-9. doi: 10.1073/pnas.79.2.395.
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