细胞协作中的抗原特异性T细胞因子：物理性质及在H-2左手（K）半区的定位
Antigen-specific T-cell factor in cell cooperation: physical properties and mapping in the left-hand (K) half of H-2.
作者信息
Munro A J, Taussig M J, Campbell R, Williams H, Lawson Y
出版信息
J Exp Med. 1974 Dec 1;140(6):1579-87. doi: 10.1084/jem.140.6.1579.
Abstract
Mouse thymus cells, educated to poly(tyrosyl,glutamyl)-polyDLalanyl--polylysyl [(T,G)-A--L], release an antigen-specific factor on brief culture in vitro. The factor cooperates with bone marrow cells in the antibody response to (T,G)-A--L in irradiated recipients. Its mol wt determined from Sephadex G100 chromatography is in the region of 50,000. The factor is removed by specific antigen-coated columns, but not by anti-immunoglobulin (anti-Fab, anti-micro, anti-Fv) adsorbents. The factor is removed by alloantisera directed against the H-2 haplotype of the strain in which it is produced. Moreover, only antisera with specificity for the K side of H-2 were successful in removing the factor activity.
摘要
受过聚（酪氨酰、谷氨酰）-聚-DL-丙氨酰-聚-L-赖氨酰[（T，G）-A-L]刺激的小鼠胸腺细胞，在体外短期培养时会释放一种抗原特异性因子。该因子在受照射受体对（T，G）-A-L的抗体应答中与骨髓细胞协同作用。通过葡聚糖凝胶G100层析测定其分子量在50,000左右。该因子可被特异性抗原包被的柱去除，但不能被抗免疫球蛋白（抗Fab、抗μ、抗Fv）吸附剂去除。该因子可被针对产生它的品系的H-2单倍型的同种抗血清去除。此外，只有对H-2的K侧具有特异性的抗血清才能成功去除因子活性。
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