Horgan J D, Lange R L
Biophys J. 1965 Nov;5(6):935-45. doi: 10.1016/S0006-3495(65)86760-1.
The respiratory control system is treated as linear with a transmission delay between ventilation and sensing points (chemoreceptors). To the accepted variables involving body gas stores, ventilatory effects, transmission effects, and steady state pH, P(CO2), P(O2) chemoreceptor response, certain detailed analysis of the central receptors have been added. By construction of a model for medullary CO(2) receptor utilizing expected values of CNS (central nervous system) circulation, CO(2) production, and tissue-buffering effects, results of experimental observation of the effects of alteration of CSF were simulated. The inclusion of CSF effects also allowed simulation of the response to alteration in inspired CO(2), hyperventilation, and the periodic breathing with prolongation of circulation time.
呼吸控制系统被视为线性系统，在通气和传感点（化学感受器）之间存在传输延迟。对于涉及身体气体储备、通气效应、传输效应以及稳态pH、P(CO2)、P(O2)化学感受器反应的公认变量，还增加了对中枢感受器的某些详细分析。通过构建一个利用中枢神经系统（CNS）循环、CO(2)产生和组织缓冲效应的期望值的延髓CO(2)受体模型，模拟了脑脊液改变效应的实验观察结果。纳入脑脊液效应还允许模拟对吸入CO(2)改变、过度通气以及循环时间延长时周期性呼吸的反应。
