Kern F, Sobotka A K, Valentine M D, Benton A W, Lichtenstein L M
J Allergy Clin Immunol. 1976 Jun;57(6):554-9. doi: 10.1016/0091-6749(76)90006-3.
Recent reports have indicated that venoms may be more beneficial than whole body extracts for the diagnosis and treatment of Hymenoptera sensitive patients. These studies were undertaken to determine the cross-reactivity among the vespid venoms. Eighteen patients who were anaphylactically sensitive to vespid venoms were studied using in vitro leukocyte histamine release. The results (venom concentration for 50% histamine release) were analyzed by linear regression analysis; there was no allergenic cross-reactivity between any of the venoms, except for a modest association between yellow hornet and white hornet venom. In spite of this result 13 of the 18 patients studied were sensitive to three or four of the venoms tested. There is no clear explanation for this observation, but it suggests the existence of multiple major allergens in the vespid venoms, some of which are cross-reactive. Since immunotherapy with inappropriate proteins may lead to the development of IgE and the possibility of clinical sensitivity and since the majority of patients were not sensitive to all venom preparations, we suggest that appropriate diagnostic studies be carried out before the institution of therapy.
最近的报告表明，对于膜翅目敏感患者的诊断和治疗，毒液可能比全虫提取物更有益。开展这些研究是为了确定胡蜂毒液之间的交叉反应性。对18名对胡蜂毒液过敏的患者进行了体外白细胞组胺释放研究。通过线性回归分析对结果（组胺释放50%时的毒液浓度）进行分析；除了黄胡蜂和白胡蜂毒液之间有适度关联外，任何毒液之间均无变应原交叉反应性。尽管有此结果，但所研究的18名患者中有13名对三种或四种测试毒液敏感。对此观察结果尚无明确解释，但这表明胡蜂毒液中存在多种主要变应原，其中一些具有交叉反应性。由于使用不适当的蛋白质进行免疫治疗可能导致IgE的产生以及临床敏感的可能性，并且由于大多数患者并非对所有毒液制剂敏感，我们建议在开始治疗前进行适当的诊断研究。
