Loshek D D, Orr J S, Solomonidis E
Br J Radiol. 1977 Dec;50(600):893-901. doi: 10.1259/0007-1285-50-600-893.
The interaction of hyperthermia and radiation on cell survival is illustrated by the increase in sensitivity to radiation caused by hyperthermia and the increase in sensitivity to hyperthermia caused by radiation. A method of expressing the total response to a combination of these two agents by means of a survival surface in three dimensions is explained and discussed. A simple mathematical model of the suface is formulated in which is a first order interaction term is separated from the two terms representing unperturbed radiation survival and unperturbed hyperthermia survival. An experiment is described in which survival data points were obtained for 77 combinations of radiation and hypertermia doses in the form of a matrix. These data points are plotted as 11 radiation survival curves and seven hyperthermia survival curves. The results are also analysed to give the parameters of the survival surface model. The model with its three components is shown to be a good approximation to the experimental results.
热疗与辐射对细胞存活的相互作用表现为热疗导致对辐射的敏感性增加，以及辐射导致对热疗的敏感性增加。本文解释并讨论了一种通过三维存活表面来表达对这两种因素组合的总反应的方法。构建了一个简单的表面数学模型，其中一阶相互作用项与代表未受干扰的辐射存活和未受干扰的热疗存活的两项分开。描述了一个实验，其中以矩阵形式获得了77种辐射和热疗剂量组合的存活数据点。这些数据点被绘制成11条辐射存活曲线和7条热疗存活曲线。还对结果进行了分析，以给出存活表面模型的参数。具有三个组成部分的模型被证明是对实验结果的良好近似。
