Loshek D D, Orr J S, Solomonidis E
Br J Radiol. 1981 Jan;54(637):40-7. doi: 10.1259/0007-1285-54-637-40.
Cell-survival data were collected to determine the survival response of asynchronous CHO cells subjects to radiation and hyperthermia. The irradiation was at room temperature 100 minutes before exposure to hyperthermia at 42 degrees C. The survival response to the combination of these two agents is expressed by means of a survival surface, a three-dimensional concept relating cell survival to heat dose and radiation dose. The survival surface could be approximately described by a survival model comprising three components of cell killing: the unperturbed radiation component, the unperturbed hyperthermia component, and the interaction component. The dependence of the radiation component and the interaction component on radiation quality were investigated by irradiating with either 60Co gamma rays, 250 kV X rays or 14.7 MeV neutrons. An analysis suggests that the interaction component and the radiation component exhibit similar dependencies on radiation quality both for the deposition of damage and the repair or accumulation of that damage.
收集细胞存活数据以确定异步CHO细胞受辐射和热疗后的存活反应。在42℃热疗前100分钟于室温下进行辐照。这两种因素联合作用下的存活反应通过存活表面来表示，存活表面是一个将细胞存活与热剂量和辐射剂量联系起来的三维概念。存活表面可通过一个包含细胞杀伤三个成分的存活模型大致描述：未受干扰的辐射成分、未受干扰的热疗成分和相互作用成分。通过用60Coγ射线、250 kV X射线或14.7 MeV中子进行辐照，研究了辐射成分和相互作用成分对辐射质量的依赖性。分析表明，无论是损伤的沉积还是损伤的修复或积累，相互作用成分和辐射成分对辐射质量都表现出相似的依赖性。
