Franco-Morselli R, Elghozi J L, Joly E, Di Giuilio S, Meyer P
Br Med J. 1977 Nov 12;2(6097):1251-4. doi: 10.1136/bmj.2.6097.1251.
Plasma adrenaline, noradrenaline, and dopamine concentrations and plasma renin activity were measured in the supine position and after standing for 10 minutes in 14 patients with sustained benign essential hypertension and in five patients with labile hypertension. Results were compared with values obtained in 11 normotensive control subjects. In controls plasma noradrenaline concentrations increased with age, while plasma adrenaline values tended to decrease with age. No significant difference in mean plasma noradrenaline was found between hypertensive and control subjects, but plasma noradrenaline seemed slightly increased in a proportion of hypertensive patients aged less than 50. Plasma adrenaline was considerably raised in both supine and standing positions in eight patients with sustained hypertension and in two with labile hypertension. Dopamine concentrations and plasma renin activity were similar in all groups studied. The finding of significantly raised plasma adrenaline concentrations in a large proportion of hypertensive patients supports the hypothesis that the activity of the sympathetic nervous system is increased in essential hypertension. Measurement of plasma adrenaline seems to be a more sensitive index of this activity than that of plasma noradrenaline.
对14例持续性良性原发性高血压患者和5例波动性高血压患者测量了卧位及站立10分钟后的血浆肾上腺素、去甲肾上腺素、多巴胺浓度以及血浆肾素活性。将结果与11名血压正常的对照者所测得的值进行比较。在对照组中，血浆去甲肾上腺素浓度随年龄增加，而血浆肾上腺素值则随年龄趋于降低。高血压患者与对照者的平均血浆去甲肾上腺素水平无显著差异，但在部分年龄小于50岁的高血压患者中，血浆去甲肾上腺素似乎略有升高。8例持续性高血压患者和2例波动性高血压患者在卧位和站立位时血浆肾上腺素均显著升高。多巴胺浓度和血浆肾素活性在所有研究组中相似。在大部分高血压患者中发现血浆肾上腺素浓度显著升高，这支持了原发性高血压患者交感神经系统活性增加的假说。与血浆去甲肾上腺素相比，测量血浆肾上腺素似乎是该活性更敏感的指标。
