谷氨酸脱氢酶：酒精性肝病中肝细胞坏死的可靠标志物。

Glutamate dehydrogenase: a reliable marker of liver cell necrosis in the alcoholic.

作者信息

Van Waes L, Lieber C S

出版信息

Br Med J. 1977 Dec 10;2(6101):1508-10. doi: 10.1136/bmj.2.6101.1508.

DOI:10.1136/bmj.2.6101.1508

PMID:589307

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1632812/

Abstract

The usefulness of blood enzyme determinations as markers of liver necrosis was tested in 100 alcoholics who underwent biopsy during clinical investigation. Mean values of glutamate dehydrogenase (GDH), serum aspartate and alanine transferase (SGOT and SGPT), ornithine carbamoyltransferase (OCT), and gamma-glutamyltranspeptidase (gamma-GTP) tended to rise with increasing liver cell necrosis, though values of SGOT, SGPT, OCT, and gamma-GTP showed considerable overlap between the 32 patients with histologically proved hepatitis and the 68 without. By contrast, GDH values showed virtually no overlap between patients with and without hepatitis, and a value of two and a half times the normal value discriminated between the two groups. Because of its easy determination and its reliable reflection of liver cell necrosis the GDH concentration should be estimated routinely in alcoholic patients.

摘要

在100名临床检查时接受活检的酗酒者中，对血液酶测定作为肝坏死标志物的实用性进行了测试。谷氨酸脱氢酶（GDH）、血清天冬氨酸和丙氨酸转氨酶（SGOT和SGPT）、鸟氨酸氨基甲酰转移酶（OCT）以及γ-谷氨酰转肽酶（γ-GTP）的均值往往随着肝细胞坏死的增加而升高，不过，在32例经组织学证实患有肝炎的患者和68例未患肝炎的患者之间，SGOT、SGPT、OCT和γ-GTP的值有相当大的重叠。相比之下，患肝炎和未患肝炎的患者之间，GDH值几乎没有重叠，两倍半正常值的GDH值可区分这两组患者。由于其易于测定且能可靠反映肝细胞坏死情况，故应定期测定酗酒患者的GDH浓度。