Cummins J E, Brewer E N, Rusch H P
J Cell Biol. 1965 Nov;27(2):337-41. doi: 10.1083/jcb.27.2.337.
Actidione, reportedly a specific inhibitor of protein synthesis, was found to reduce the incorporation of labeled amino acids into proteins of the slime mold Physarum polycephalum without drastically inhibiting the incorporation of nucleic acid precursors into RNA. This inhibitor was found to completely block the ensuing mitosis if it was added at any time between telophase and late prophase. Plasmodia given Actidione in late prophase (about the time of nucleolar dissolution) went on through telophase to reconstruction even though nuclear amino acid incorporation was drastically reduced during that period.
放线菌酮据报道是一种蛋白质合成的特异性抑制剂，它能减少标记氨基酸掺入多头绒泡菌的蛋白质中，而不会显著抑制核酸前体掺入RNA。如果在末期和早前期之间的任何时间添加这种抑制剂，会发现它能完全阻断随后的有丝分裂。在早前期（大约核仁溶解时）给予放线菌酮的原质团即使在那段时间核氨基酸掺入大幅减少，仍能经历末期进行重建。
