Meisels A, Bégin R, Schneider V
Cancer. 1977 Dec;40(6):3076-81. doi: 10.1002/1097-0142(197712)40:6<3076::aid-cncr2820400647>3.0.co;2-u.
Age at first coitus and use of oral contraceptives were studied in a highly homogeneous population (French Canadian) during a cytologic cervical cancer screening program. Both factors were known in 84,540 women without cervical lesions and in 2017 patients with mild and moderate dysplasia. Highly significant correlations were found between: early onset of sexual activity and occurrence of dysplasia; oral contraceptive use and occurrence of dysplasia; early age at first coitus and oral contraceptive use. When correlated for age at first coitus, there was a significant excess of dysplasias in oral contraceptive users. Dysplasia of the uterine cervix behaves epidemiologically like carcinoma in situ and invasive squamous carcinoma, that is, essentially as a venereal disease. It remains to be seen whether all dysplasias form one continuum or whether there are two morphologically similar but biologically distinct forms of dysplasia: one more frequent, regressing spontaneously, the other relatively rare, progressing to carcinoma in situ and invasive squamous carcinoma of the cervix.
在一项宫颈癌细胞学筛查项目中，对一个高度同质的人群（法裔加拿大人）的首次性交年龄和口服避孕药的使用情况进行了研究。在84540名无宫颈病变的女性以及2017名患有轻度和中度发育异常的患者中，这两个因素都是已知的。研究发现：性活动开始早与发育异常的发生之间；口服避孕药的使用与发育异常的发生之间；首次性交年龄早与口服避孕药的使用之间，均存在高度显著的相关性。当按首次性交年龄进行相关性分析时，口服避孕药使用者的发育异常明显过多。子宫颈发育异常在流行病学上表现得如同原位癌和浸润性鳞状细胞癌，也就是说，本质上是一种性病。所有发育异常是否构成一个连续体，或者是否存在两种形态相似但生物学上不同的发育异常形式：一种更常见，可自发消退，另一种相对罕见，会进展为宫颈原位癌和浸润性鳞状细胞癌，还有待观察。
