Beex L, Ross A, Smals A, Kloppenborg P
Cancer Treat Rep. 1977 Oct;61(7):1291-5.
Total serum thyroxine and triiodothyronine levels in a group of 15 patients with advanced mammary carcinoma significantly increased during weekly treatment with 5-fluorouracil, whereas serum free thyroxine levels and serum thyroid stimulating hormone levels were unchanged. No clinical signs of hyperthyroidism in these treated patients have been observed.
在一组15例晚期乳腺癌患者中，每周使用5-氟尿嘧啶治疗期间，血清总甲状腺素和三碘甲状腺原氨酸水平显著升高，而血清游离甲状腺素水平和血清促甲状腺激素水平未发生变化。在这些接受治疗的患者中未观察到甲状腺功能亢进的临床体征。
