Adami H O, Rimsten A, Thorén L, Vegelius J, Wide L
Acta Chir Scand. 1978;144(2):89-97.
Investigations concerning a possible influence of thyroid disease and function on the risk for breast cancer have given contradictory results--although a slight hypothyroidism was repeatedly suggested and supported by increased thyrotropin concentrations and exaggerated TRH-responses. The selection of proper controls was stressed and in this study 179 consecutively diagnosed breast cancer patients were compared with 179 age-matched controls chosen from a computerized population register. The prevalence of thyroid disease and thyroxine treatment showed no differences between the groups. Slight but significant differences were found in the patient group--with a higher mean value for thyrotropin, reverse triodothyronine and T3-resin uptake and a lower mean value for triiodothyronine. No difference was found concerning thyroxine. This pattern of changes was inconsistent with a hypothyroidism, but has recently been found in many non-thyroidal diseases. It is suggested that it may represent a secondary and probably extrathyroidal metabolic change, most likely due to an altered peripheral conversion of the thyroxine.
关于甲状腺疾病及功能对乳腺癌风险可能产生的影响的研究得出了相互矛盾的结果——尽管促甲状腺素浓度升高和促甲状腺激素释放激素反应增强反复表明并支持存在轻度甲状腺功能减退。强调了选择合适对照的重要性，在本研究中，将179例连续确诊的乳腺癌患者与从计算机化人口登记册中选取的179例年龄匹配的对照进行了比较。两组之间甲状腺疾病和甲状腺素治疗的患病率无差异。在患者组中发现了轻微但显著的差异——促甲状腺素、反三碘甲状腺原氨酸和T3树脂摄取的平均值较高，而三碘甲状腺原氨酸的平均值较低。甲状腺素方面未发现差异。这种变化模式与甲状腺功能减退不一致，但最近在许多非甲状腺疾病中也有发现。有人认为，这可能代表一种继发性且可能是甲状腺外的代谢变化，很可能是由于甲状腺素外周转化改变所致。
