Kjellman N I, Lanner A, Roth A
Clin Allergy. 1977 Sep;7(5):465-71. doi: 10.1111/j.1365-2222.1977.tb01477.x.
Thirty children with hay fever were studied with in vivo and in vitro tests during rush hyposensitization with Timothy pollen. Clinical assessment was made with the aid of diaries during one season before, and three seasons after, the start of the immunotherapy. When the serum level of IgE increased more than 10% during the first week of the therapy, symptoms were mostly alleviated during the following seasons. An alleviation was rarely found in children with decreasing or unchanged serum IgE levels. No predictive information as to the clinical effect of the immunotherapy was obtained from skin or provocation tests, nor from Timothy-specific antibodies of the IgG or IgE classes. It is proposed that serum IgE determinations should be performed before, and 1 week after, the start of rush hyposensitization in order to find probable therapeutic failures.
对30名患有花粉热的儿童在使用梯牧草花粉进行快速减敏治疗期间进行了体内和体外测试。在免疫治疗开始前的一个季节以及开始后的三个季节，借助日记进行临床评估。当治疗第一周血清IgE水平升高超过10%时，随后几个季节的症状大多会得到缓解。血清IgE水平降低或不变的儿童很少出现症状缓解。皮肤或激发试验以及IgG或IgE类别的梯牧草特异性抗体均未提供关于免疫治疗临床效果的预测信息。建议在快速减敏治疗开始前和开始后1周进行血清IgE测定，以发现可能的治疗失败情况。
