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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Clin Exp Pharmacol Physiol. 1977 Nov-Dec;4(6):575-7. doi: 10.1111/j.1440-1681.1977.tb02687.x.

The effects of acetylcholine on the frequency-force relationship in isolated atria of the dog were investigated in spontaneously beating and electrically paced preparations, which were suspended in a bath perfused with arterial blood from a carotid artery of a heparinized donor dog. 2. The developed tension at low frequencies of stimulation was less suppressed than at higher frequencies by an infusion of a relatively low dose level (1-2 microgram/min) of acetylcholine. At higher doses (4-10 microgram/min), acetylcholine suppressed the tension development at any given frequency.

在自发搏动和电刺激的犬离体心房标本中，研究了乙酰胆碱对频率-张力关系的影响。这些标本悬浮于一个浴槽中，该浴槽由来自肝素化供体犬颈动脉的动脉血灌注。2. 输注相对低剂量水平（1-2微克/分钟）的乙酰胆碱时，低频刺激下产生的张力比高频刺激下受到的抑制作用小。在较高剂量（4-10微克/分钟）时，乙酰胆碱在任何给定频率下均抑制张力的产生。

Clin Exp Pharmacol Physiol. 1977 Nov-Dec;4(6):575-7. doi: 10.1111/j.1440-1681.1977.tb02687.x.

The effects of acetylcholine on the frequency-force relationship in isolated atria of the dog were investigated in spontaneously beating and electrically paced preparations, which were suspended in a bath perfused with arterial blood from a carotid artery of a heparinized donor dog. 2. The developed tension at low frequencies of stimulation was less suppressed than at higher frequencies by an infusion of a relatively low dose level (1-2 microgram/min) of acetylcholine. At higher doses (4-10 microgram/min), acetylcholine suppressed the tension development at any given frequency.

在自发搏动和电刺激的犬离体心房标本中，研究了乙酰胆碱对频率-张力关系的影响。这些标本悬浮于一个浴槽中，该浴槽由来自肝素化供体犬颈动脉的动脉血灌注。2. 输注相对低剂量水平（1-2微克/分钟）的乙酰胆碱时，低频刺激下产生的张力比高频刺激下受到的抑制作用小。在较高剂量（4-10微克/分钟）时，乙酰胆碱在任何给定频率下均抑制张力的产生。