脑组蛋白对体外DNA合成的影响。
Effect of histones from brain on DNA-synthesis in vitro.
作者信息
Jahn G, Szijan I, Burdman J A
出版信息
Experientia. 1977 Dec 15;33(12):1588-90. doi: 10.1007/BF01934014.
PMID:590447
Abstract
The results of these experiments demonstrate that histones from brain inhibit the replication of DNA in vitro. A similar effect is observed with polylysine or polyarginine. The reversion of inhibition by polyglutamic acid or acidic proteins is completed in all cases except when the DNA is previously complexed with histones, polyarginine or polylysine. This suggest that histones masking of DNA towards the polymerases involves electrostatic forces.
摘要
这些实验结果表明，来自大脑的组蛋白在体外抑制DNA复制。聚赖氨酸或聚精氨酸也观察到类似效果。除了DNA事先与组蛋白、聚精氨酸或聚赖氨酸复合的情况外，在所有情况下聚谷氨酸或酸性蛋白都能完全逆转这种抑制作用。这表明组蛋白对DNA聚合酶的掩盖作用涉及静电力。
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