[组蛋白对再生大鼠肝脏中DNA合成的刺激作用]
[Stimulating effect of histones on DNA synthesis in the regenerating rat liver].
作者信息
Smirnova N V, Smirnova T E, Rodionov V M
出版信息
Biokhimiia. 1976 Jul;41(6):1023-7.
PMID:1027484
Abstract
Effect of exogenous histones, nuclear globulins and acid proteins on DNA synthesis is studied in regenerating liver of rats in which the synthesis of their own proteins and thus DNA replication are inhibited by cycloheximide. In these conditions histones from regenerating rat liver are found to stimulate 3H-thymidine incorporation into DNA of hepatectomyzed rat liver. Nuclear globulins and acid proteins from regenerating liver, and histones from intact liver produced no stimulating effect on DNA sythesis.
摘要
在大鼠再生肝中研究了外源性组蛋白、核球蛋白和酸性蛋白对DNA合成的影响，在这些大鼠中，环己酰亚胺抑制了它们自身蛋白质的合成，从而抑制了DNA复制。在这些条件下，发现来自再生大鼠肝脏的组蛋白能刺激3H-胸腺嘧啶掺入肝切除大鼠肝脏的DNA中。来自再生肝脏的核球蛋白和酸性蛋白，以及来自完整肝脏的组蛋白对DNA合成没有刺激作用。
Zotero 插件