Raj S G, Berger M J, Grimes E M, Taymor M L
Fertil Steril. 1977 Dec;28(12):1280-4. doi: 10.1016/s0015-0282(16)42969-9.
Ten infertile patients with polycystic ovarian disease were treated with 18 cycles of "pure" human pituitary follicle-stimulating hormone (HP-FSH) and 10 cycles of human menopausal gonadotropin (HMG) consisting of FSH and luteinizing hormone (LH) in a 1:1 ratio. Human chorionic gonadotropin was used to trigger ovulation when optimal follicular development was achieved as judged by urinary estrogen determinations. Of the 18 cycles utilizing HP-FSH, 14 were presumptively ovulatory, 2 were conceptual, and in 5 cycles ovarian enlargement was noted. Of the 10 HMG cycles, none was ovulatory, no conceptions resulted, and 6 instances of hyperstimulation were noted. Pretreatment serum LH levels were significantly higher than normal follicular phase values. These observations suggest that endogenous LH levels in patients with polycystic ovaries are quite adequate for follicular development so that the administration of exogenous LH is unwarranted. Furthermore, the data suggest that HP-FSH or low-LH-containing HMG may prove to be an additional safe and effective nonsurgical treatment modality for patients who are anovulatory because of polycystic ovaries.
10例多囊卵巢疾病不孕患者接受了18个周期的“纯”人垂体促卵泡激素（HP - FSH）治疗以及10个周期的人绝经期促性腺激素（HMG）治疗，后者由促卵泡激素（FSH）和促黄体生成素（LH）按1:1比例组成。当通过尿雌激素测定判断达到最佳卵泡发育时，使用人绒毛膜促性腺激素触发排卵。在使用HP - FSH的18个周期中，推测有14个周期排卵，2个周期受孕，5个周期观察到卵巢增大。在10个HMG周期中，无排卵情况，未受孕，观察到6例卵巢过度刺激。治疗前血清LH水平显著高于正常卵泡期值。这些观察结果表明，多囊卵巢患者的内源性LH水平足以支持卵泡发育，因此无需给予外源性LH。此外，数据表明，HP - FSH或含低LH的HMG可能被证明是多囊卵巢所致无排卵患者的另一种安全有效的非手术治疗方式。
