Aleksandrov A A, Van Nguyen U t
Fiziol Zh SSSR Im I M Sechenova. 1977 Nov;63(11):1505-10.
The effects of GABA AND PHENYBUT (BEta-phenyl-gamma-aminobutyric acid) on the dorsal (DRP) and ventral (VPR) root potentials were studied in the isolated frog spinal cord. The direct action of these agents on the neuronal membranes was studied by means of the microiontophoretic method in the cat cerebral cortex. Phenybut, like GABA, SUPPRESSES DRP and VRP at the spinal cord level, but it prolongs the duration of DRP and VRP rising phase and at the same time depresses the VR reflexes. Phenybut microiontophoretic application does not considerably affect the neuronal activity whereas GABA exerts an obvious inhibitory action. Differences in the mechanisms of GABA and phenybut actions on the c. n. s. elements are discussed.
在离体蛙脊髓中研究了γ-氨基丁酸（GABA）和苯丁胺（β-苯基-γ-氨基丁酸）对背根电位（DRP）和腹根电位（VPR）的影响。通过微离子电泳法在猫大脑皮层研究了这些药物对神经元膜的直接作用。苯丁胺与GABA一样，在脊髓水平抑制DRP和VRP，但它延长了DRP和VRP上升期的持续时间，同时抑制VR反射。微离子电泳施加苯丁胺对神经元活动没有显著影响，而GABA则发挥明显的抑制作用。讨论了GABA和苯丁胺对中枢神经系统元件作用机制的差异。
