Aleksandrov A A, Lenkov D N
Neirofiziologiia. 1975;7(5):527-31.
The effect of the convulsant bemegride (beta-ethyl-beta-methyl-glutharimide) on the electronic potentials in the frog spinal roots was investigated in situ. Intravenous injection of the bemegride subconvulsant doses (6.8 +/- 2.7 mg/kg) depressed rapidly the electrotonic dorsal root potentials (DRP) evoked by a stimulation of the adjacent dorsal root (DR) or the ventral root (VR). They were reduced by 55--67% 3-6 min after the bemegride injection. The effect of bemegride was reversible and the DRP amplitude restored its initial value within an hour. Ventral root potentials after bemegride injection revealed only greater amplitude fluctuations. A conclusion is made that bemegride is a selective and potent depressor of the primary afferent depolarization in the frog spinal cord.
在原位研究了惊厥剂美解眠（β-乙基-β-甲基戊二酰亚胺）对蛙脊髓神经根电电位的影响。静脉注射亚惊厥剂量的美解眠（6.8±2.7毫克/千克）可迅速抑制由刺激相邻背根（DR）或腹根（VR）诱发的电紧张性背根电位（DRP）。美解眠注射后3 - 6分钟，它们降低了55 - 67%。美解眠的作用是可逆的，DRP振幅在一小时内恢复到初始值。美解眠注射后的腹根电位仅显示出更大的振幅波动。得出的结论是，美解眠是蛙脊髓中初级传入去极化的一种选择性强效抑制剂。
