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黄曲霉毒素B1：体外与DNA结合及体内RNA代谢的改变。

Aflatoxin B1: binding to DNA in vitro and alteration of RNA metabolism in vivo.

作者信息

Sporn M B, Dingman C W, Phelps H L, Wogan G N

出版信息

Science. 1966 Mar 25;151(3717):1539-41. doi: 10.1126/science.151.3717.1539.

DOI:10.1126/science.151.3717.1539
PMID:5909585
Abstract

Aflatoxin B(1) binds to both native and denatured DNA, as shown by spectroscopy and equilibrium dialysis. It also strongly inhibits incorporation of cytidine into rat liver nuclear RNA and lowers the RNA content of the nucleus. The extremle toxicity and carcinogenicity of aflatoxin B(1) may be direct results of the affinity of this agent for DNA.

摘要

黄曲霉毒素B(1)与天然DNA和变性DNA均能结合，这已通过光谱学和平衡透析法得到证实。它还能强烈抑制胞苷掺入大鼠肝细胞核RNA中，并降低细胞核的RNA含量。黄曲霉毒素B(1)的极高毒性和致癌性可能是该物质对DNA亲和力的直接结果。

相似文献

1
Aflatoxin B1: binding to DNA in vitro and alteration of RNA metabolism in vivo.黄曲霉毒素B1：体外与DNA结合及体内RNA代谢的改变。
Science. 1966 Mar 25;151(3717):1539-41. doi: 10.1126/science.151.3717.1539.
2
Some studies of the effects of aflatoxin B1 in vivo and in vitro on nucleic acid synthesis in rat and mouse.一些关于黄曲霉毒素B1在体内和体外对大鼠和小鼠核酸合成影响的研究。
Chem Biol Interact. 1976 Jun;13(3-4):257-77. doi: 10.1016/0009-2797(76)90079-x.
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[Inhibition by aflatoxin of hepatic RNA synthesis in rats].[黄曲霉毒素对大鼠肝脏RNA合成的抑制作用]
Bull Soc Chim Biol (Paris). 1965;47(8):1724-5.
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Aflatoxin: effect on cultured heteroploid human embryonic lung cells.黄曲霉毒素：对培养的异倍体人胚肺细胞的影响
Nature. 1965 Oct 23;208(5008):345-7. doi: 10.1038/208345a0.
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Induction of chromosome aberrations by aflatoxin.黄曲霉毒素诱导染色体畸变
Nature. 1965 Jul 24;207(995):433-4. doi: 10.1038/207433a0.
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The effect of aflatoxin B 1 on normal and cortisol-stimulated rat liver ribonucleic acid synthesis.黄曲霉毒素B1对正常及经皮质醇刺激的大鼠肝脏核糖核酸合成的影响。
Biochem J. 1972 Nov;130(2):619-29. doi: 10.1042/bj1300619.
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Transcriptional effect of aflatoxin B1 on cytosine and/or hypoxanthine containing DNAs.黄曲霉毒素B1对含胞嘧啶和/或次黄嘌呤的DNA的转录作用。
Mol Cell Biochem. 1991 Apr 24;103(1):1-8. doi: 10.1007/BF00229587.
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The effect of aflatoxin B 1 , aflatoxin B 2 and sterigmatocystin on nuclear deoxyribonucleases from rat and mouse livers.黄曲霉毒素B1、黄曲霉毒素B2和柄曲霉素对大鼠和小鼠肝脏细胞核脱氧核糖核酸酶的影响。
Chem Biol Interact. 1971 Oct;3(5):353-61. doi: 10.1016/0009-2797(71)90015-9.
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[Effect of aflatoxin B1 on DNA enzymatic methylation and secondary structures of the rat liver].黄曲霉毒素B1对大鼠肝脏DNA酶促甲基化及二级结构的影响
Vopr Onkol. 1989;35(1):48-52.
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Inhibition of rat-liver RNA polymerase in vitro by aflatoxin B1 in the presence of microsomal fraction.在微粒体组分存在的情况下，黄曲霉毒素B1对大鼠肝脏RNA聚合酶的体外抑制作用。
Eur J Biochem. 1974 Mar 1;42(2):333-9. doi: 10.1111/j.1432-1033.1974.tb03344.x.

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