黄曲霉毒素B1：体外与DNA结合及体内RNA代谢的改变。
Aflatoxin B1: binding to DNA in vitro and alteration of RNA metabolism in vivo.
作者信息
Sporn M B, Dingman C W, Phelps H L, Wogan G N
出版信息
Science. 1966 Mar 25;151(3717):1539-41. doi: 10.1126/science.151.3717.1539.
PMID:5909585
Abstract
Aflatoxin B(1) binds to both native and denatured DNA, as shown by spectroscopy and equilibrium dialysis. It also strongly inhibits incorporation of cytidine into rat liver nuclear RNA and lowers the RNA content of the nucleus. The extremle toxicity and carcinogenicity of aflatoxin B(1) may be direct results of the affinity of this agent for DNA.
摘要
黄曲霉毒素B(1)与天然DNA和变性DNA均能结合，这已通过光谱学和平衡透析法得到证实。它还能强烈抑制胞苷掺入大鼠肝细胞核RNA中，并降低细胞核的RNA含量。黄曲霉毒素B(1)的极高毒性和致癌性可能是该物质对DNA亲和力的直接结果。
Zotero 插件