内部灌注轴突：两种不同阴离子对离子电导的影响。

Internally perfused axons: effects of two different anions on ionic conductance.

作者信息

Adelman W J, Dyron F M, Senft J P

出版信息

Science. 1966 Mar 18;151(3716):1392-4. doi: 10.1126/science.151.3716.1392.

DOI:10.1126/science.151.3716.1392

Abstract

Voltage-clamizped giant axons of squid, internally perfused with potassiumt chloride solutions, showed reduced initial transient memnbrane conductance to voltage and increased overall (leakage) conductance. Unclamtped axons showed reduced action and resting potentials. Ionic conductances and memtbrane potentials were maintained or restored by perfusion with potassiuwn fluoride solutions. As much as 90 percent of internal fluoride could be replaced with chloride without alterationt of normal properties of membrane.

摘要

用氯化钾溶液进行内部灌注的鱿鱼电压钳制巨轴突，对电压的初始瞬态膜电导降低，整体（泄漏）电导增加。未钳制的轴突动作电位和静息电位降低。通过用氟化钾溶液灌注可维持或恢复离子电导和膜电位。高达90%的内部氟化物可用氯化物替代，而不会改变膜的正常特性。