Cypess R H, Ebersole J L, Molinari J A
Int Arch Allergy Appl Immunol. 1977;55(1-6):496-503. doi: 10.1159/000231963.
Radial immunodiffusion analysis was performed on intestinal perfusates from ICR/CD1 mice following oral infection and challenge with viable Heligosomoides polygyrus larvae. Infection of these mice resulted in an alteration in the amount and class of immunoglobulins, as well as anti-parasitic antibody. Specific IgA peaked at 3 days post-infection and then showed a gradual decline until day 21. This rapid elevation in IgA levels was temporally associated with early events in the parasite life cycle, and the increase in IgA was significantly higher in mice infected twice with H. polygyrus prior to challenge. Differences in both the concentrations and kinetics of specific IgA and IgG1 were also observed in the perfusates from these mice when compared to those noted for animals infected only once.
对经口感染并接受活的多形螺旋线虫幼虫攻击后的ICR/CD1小鼠的肠道灌流液进行了放射免疫扩散分析。这些小鼠受到感染后，免疫球蛋白的数量和类别以及抗寄生虫抗体发生了改变。特异性IgA在感染后3天达到峰值，然后逐渐下降，直至第21天。IgA水平的这种快速升高在时间上与寄生虫生命周期的早期事件相关，并且在攻击前两次感染多形螺旋线虫的小鼠中，IgA的增加明显更高。与仅感染一次的动物相比，在这些小鼠的灌流液中还观察到特异性IgA和IgG1在浓度和动力学方面的差异。
