Molinari J A, Ebersole J L, Cypess R H
J Parasitol. 1978 Apr;64(2):233-8.
Sera from ICR/CD mice were assayed by radial immunodiffusion following oral infection and challenge with Heligmosomoides polygyrus larvae. Infection of these mice was found to alter the concentrations and classes of immunoglobulins, as well as the levels of antiparasitic antibody. Challenge of single- or multiple-infected mice with viable larvae resulted in the appearance of anti-H. polygyrus IgA and IgG in the serum. The kinetics of the detection for both of these antibody classes were consistent with an anamnestic response to an antigen isolated from adult nematodes. There also appeared to be an association in resistant mice of serum IgA levels with early and late events in the life cycle of the parasite.
在口服感染并受到多形螺旋线虫幼虫攻击后，通过放射免疫扩散法对ICR/CD小鼠的血清进行检测。发现这些小鼠的感染会改变免疫球蛋白的浓度和类别，以及抗寄生虫抗体的水平。用活幼虫攻击单次或多次感染的小鼠，导致血清中出现抗多形螺旋线虫IgA和IgG。这两类抗体的检测动力学与对从成年线虫分离的抗原的回忆反应一致。在抗性小鼠中，血清IgA水平似乎也与寄生虫生命周期中的早期和晚期事件有关。
