AY-9944对5α-胆甾-8,14-二烯-3β-醇和5α-胆甾-7,14-二烯-3β-醇δ14-双键酶促还原反应的抑制作用
Inhibition of enzymatic reduction of delta 14-double bond of 5 alpha-cholesta-8,14-dien-3 beta-ol and 5 alpha-cholesta-7,14-dien-3 beta-ol by AY-9944.
作者信息
Lutsky B N, Hsiung H M, Schroepfer G J
出版信息
Lipids. 1975 Jan;10(1):9-11. doi: 10.1007/BF02532186.
PMID:1123977
Abstract
AY-994 (trans-1,4-bis-(2-chlorobenzyl-aminomethyl) cyclohexane dihydrochloride), a potent inhibitor of the enzymatic reduction of the delta 7-double bond of delta 5,7-sterols, has been shown to inhibit, at higher concentrations (10-4 M), the enzymatic reduction of the delta 14-double bond of cholesta-8,14-dien-3 beta-ol and cholesta-7,14-dien-3 beta-ol.
摘要
AY - 994（反式-1,4 - 双 -（2 - 氯苄基 - 氨甲基）环己烷二盐酸盐）是一种有效的δ5,7 - 甾醇δ7 - 双键酶促还原抑制剂，已表明在较高浓度（10 - 4 M）时，它能抑制胆甾 - 8,14 - 二烯 - 3β - 醇和胆甾 - 7,14 - 二烯 - 3β - 醇的δ14 - 双键酶促还原。
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