对受抑制的乙酰胆碱酯酶的脱烷基化研究。
Dealkylation studies on inhibited acetylcholinesterase.
作者信息
Coult D B, Marsh D J, Read G
出版信息
Biochem J. 1966 Mar;98(3):869-73. doi: 10.1042/bj0980869.
Abstract
- A rapid method for measuring the rate of dealkylation of organophosporus-inhibited enzymes is described. 2. The dealkylation rates have been measured for acetylcholinesterase inhibited by isopropyl, sec.-butyl, 1,2-dimethylpropyl, 1,2,2-trimethylpropyl and cyclohexyl methylphosphonofluoridate, and by di-isopropyl phosphorofluoridate; they are first-order under the conditions used.
摘要
- 本文描述了一种快速测定有机磷抑制酶脱烷基化速率的方法。2. 已测定了被异丙基、仲丁基、1,2 - 二甲基丙基、1,2,2 - 三甲基丙基和环己基甲基膦酰氟以及二异丙基氟磷酸酯抑制的乙酰胆碱酯酶的脱烷基化速率；在所使用的条件下，它们呈一级反应。
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Dealkylation studies on inhibited acetylcholinesterase.对受抑制的乙酰胆碱酯酶的脱烷基化研究。
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2
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本文引用的文献
1
Chemical nature of the DFP-binding site of pseudocholinesterase.假性胆碱酯酶的二异丙基氟磷酸酯结合位点的化学性质。
Biochim Biophys Acta. 1959 Aug;34:573-5. doi: 10.1016/0006-3002(59)90320-8.
2
ANTIDOTAL ACTION OF PYRIDINIUM OXIMES IN ANTICHOLINESTERASE POISONING; COMPARATIVE EFFECTS OF SOMAN, SARIN, AND NEOSTIGMINE ON NEUROMUSCULAR FUNCTION.吡啶肟类化合物在抗胆碱酯酶中毒中的解毒作用；梭曼、沙林和新斯的明对神经肌肉功能的比较影响。
Toxicol Appl Pharmacol. 1963 Nov;5:685-701. doi: 10.1016/0041-008x(63)90062-0.
3
Protection against the lethal effects of organophosphates by pyridine-2-aldoxime methiodide.碘化吡啶-2-醛肟对有机磷酸酯致死效应的防护作用。
Br J Pharmacol Chemother. 1957 Dec;12(4):438-46. doi: 10.1111/j.1476-5381.1957.tb00162.x.
4
The reactivation by oximes and hydroxamic acids of cholinesterase inhibited by organo-phosphorus compounds.肟类和异羟肟酸类化合物对有机磷化合物抑制的胆碱酯酶的复活作用。
Br J Pharmacol Chemother. 1955 Dec;10(4):462-5. doi: 10.1111/j.1476-5381.1955.tb00106.x.
5
Effect of nicotinhydroxamic acid methiodide on human plasma cholinesterase inhibited by organophosphates containing a dialkylphosphato group.烟碱异羟肟酸甲碘化物对被含二烷基磷酸酯基团的有机磷酸酯抑制的人血浆胆碱酯酶的作用。
Br J Pharmacol Chemother. 1955 Sep;10(3):356-62. doi: 10.1111/j.1476-5381.1955.tb00884.x.
6
The mechanism of inhibition of cholinesterases by organophosphorus compounds.有机磷化合物对胆碱酯酶的抑制机制。
Biochem J. 1953 Dec;55(5):763-6. doi: 10.1042/bj0550763.
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