双复磷对猪体内有机磷酸酯抑制的胆碱酯酶活性的重新激活作用。
Obidoxime reactivation of organophosphate-inhibited cholinesterase activity in pigs.
作者信息
Gyrd-Hansen N, Kraul I
出版信息
Acta Vet Scand. 1984;25(1):86-95. doi: 10.1186/BF03547282.
The ability of obidoxime to reactivate organophosphate-inhibited cholinesterases was studied in pigs treated with either trichlorfon, dichlorvos or coumaphos. In 6 pigs Cholinesterase activity was measured in the blood samples both before and after in vitro reactivation with obidoxime. Three pigs were treated with obidoxime 6 h after administration of the organophosphates in order to study the possibility of in vivo reactivation. The results show a close correlation between the ability of obidoxime to reactivate the inhibited cholinesterases in vitro and in vivo. However, there was a marked difference in the possibility of reactivation between the 3 organophosphates. Thus no reactivation was possible after treatment with dichlorvos, while reactivation could be achieved for at least 6 h after administration of trichlorfon. After coumaphos treatment reactivation with obidoxime was possible for more than 24 h.
在接受敌百虫、敌敌畏或蝇毒磷治疗的猪身上研究了氯解磷定重新激活有机磷酸酯抑制的胆碱酯酶的能力。对6头猪，在体外使用氯解磷定重新激活前后，均对血样中的胆碱酯酶活性进行了测量。为研究体内重新激活的可能性，3头猪在给予有机磷酸酯6小时后用氯解磷定进行治疗。结果表明，氯解磷定在体外和体内重新激活被抑制胆碱酯酶的能力之间存在密切相关性。然而，3种有机磷酸酯在重新激活的可能性上存在显著差异。因此，用敌敌畏治疗后不可能重新激活，而在给予敌百虫后至少6小时可以实现重新激活。用蝇毒磷治疗后，用氯解磷定重新激活超过24小时都是可能的。
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