Hall R, Turner-Warwick M, Doniach D
Clin Exp Immunol. 1966 Jul;1(3):285-96.
Thyroid and gastric autoimmunity occurred more frequently in patients with iodide goitre and those with intrinsic asthma than in patients with extrinsic asthma or age- and sex-matched controls. It is suggested that iodide administration is more likely to lead to goitre and hypothyroidism in the intrinsic asthmatic group, where latent thyroid autoimmunity is common, by aggravation of an existing organification defect in the thyroid. Latent Graves' disease recognized by failure of suppression of the thyroid radioiodine uptake by triiodothyronine may also be responsible for some cases of iodide goitre.
与外源性哮喘患者或年龄及性别匹配的对照组相比,碘性甲状腺肿患者和内源性哮喘患者中甲状腺和胃自身免疫更为常见。有迹象表明,在潜在甲状腺自身免疫常见的内源性哮喘组中,由于甲状腺中现有有机化缺陷的加重,碘给药更有可能导致甲状腺肿和甲状腺功能减退。三碘甲状腺原氨酸抑制甲状腺放射性碘摄取失败所识别的潜在格雷夫斯病也可能是某些碘性甲状腺肿病例的病因。