Caspary E A, Feinmann E L, Field E J
Br Med J. 1973 Jan 6;1(5844):15-6. doi: 10.1136/bmj.1.5844.15.
Studies of lymphocyte sensitization in patients with asthma showed that the intrinsic and extrinsic forms of the disease fell into two distinct groups. Intrinsic disease showed a general sensitization to a number of non-specific antigens, while the extrinsic form had only slight elevation above normal values. These findings suggest that intrinsic asthma results from a defect of general immunity, whereas extrinsic asthma is a specific sensitization.
对哮喘患者淋巴细胞致敏作用的研究表明,该疾病的内因性和外因性形式分为两个不同的组。内因性疾病表现出对多种非特异性抗原的普遍致敏,而外因性形式仅比正常值略有升高。这些发现表明,内因性哮喘是由全身免疫缺陷引起的,而外因性哮喘是一种特异性致敏。