Crowle A J, Hu C C
Clin Exp Immunol. 1966 Jul;1(3):323-35.
Adult immunocompetent mice vaccinated with protein antigens in water-in-oil emulsion so as to develop immediate and delayed hypersensitivities resist developing the latter if they are treated with the immunizing antigen in aqueous solution before or during the sensitization period. If the treatments are given during or after vaccination this resistance is directly proportional to their intensity and inversely proportional to the degree of hypersensitivity which has developed when they are begun. But when the treatments are given before vaccination such split tolerance is more pronounced and seems to be directly proportional more to the degree of humoral antibody production existing at the time of vaccination than to the intensity of treatments. The characteristics of this antigenically specific selective unresponsiveness suggest that it may result from a competitive maturation or differentiation of primitive immunocytes: upon exposure to protein antigens in forms not readily able to induce delayed hypersensitivity, the potential functions of these immunocytes for making circulating antibodies may be pre-empted at the expense of such capacity to develop into cells making the antibody of delayed hypersensitivity.
用油水乳剂中的蛋白质抗原对成年免疫活性小鼠进行接种，使其产生速发型和迟发型超敏反应。如果在致敏期之前或期间用免疫抗原的水溶液对其进行处理，这些小鼠就会抵抗迟发型超敏反应的发生。如果在接种期间或之后进行处理，这种抵抗力与其强度成正比，与开始处理时已产生的超敏反应程度成反比。但是，当在接种前进行处理时，这种分裂耐受性更为明显，似乎更多地与接种时存在的体液抗体产生程度直接相关，而不是与处理强度直接相关。这种抗原特异性选择性无反应性的特征表明，它可能是由于原始免疫细胞的竞争性成熟或分化所致：当暴露于不易诱导迟发型超敏反应的形式的蛋白质抗原时，这些免疫细胞产生循环抗体的潜在功能可能会以牺牲其发育成产生迟发型超敏反应抗体的细胞的能力为代价而被抢先占据。
