正常和肿瘤细胞系中DNA、RNA及核蛋白的合成。3. 小鼠腹水瘤细胞。
The synthesis of DNA, RNA, and nuclear protein in normal and tumor strain cells. 3. Mouse ascites tumor cells.
作者信息
Seed J
出版信息
J Cell Biol. 1966 Feb;28(2):257-61. doi: 10.1083/jcb.28.2.257.
Abstract
Interferometric and photometric measurements have been made on replicating mouse ascites tumor cell cultures. From a study of the relations between successive physical measurements on individual cells, it was found that whereas the net syntheses of nuclear RNA and nuclear protein are closely associated during interphase, they are dissociated from DNA replication to a significant extent. These results agree with others reported in replicating cell strains derived from tumors. In auxiliary experiments an attempt was made to block the initiation of DNA synthesis by X-irradiation: although large amounts of nuclear protein accumulated in some cells in the absence of DNA synthesis, the inability to hold the DNA block for an interphase time prevented a quantitative analysis of the results.
摘要
已对复制中的小鼠腹水肿瘤细胞培养物进行了干涉测量和光度测量。通过对单个细胞连续物理测量之间关系的研究发现，在间期，核RNA和核蛋白的净合成密切相关，但它们在很大程度上与DNA复制解离。这些结果与从肿瘤衍生的复制细胞系中报道的其他结果一致。在辅助实验中，试图通过X射线照射来阻断DNA合成的起始：尽管在没有DNA合成的情况下一些细胞中积累了大量核蛋白，但无法将DNA阻断维持一个间期时间，从而妨碍了对结果的定量分析。
相似文献
1
The synthesis of DNA, RNA, and nuclear protein in normal and tumor strain cells. 3. Mouse ascites tumor cells.正常和肿瘤细胞系中DNA、RNA及核蛋白的合成。3. 小鼠腹水瘤细胞。
J Cell Biol. 1966 Feb;28(2):257-61. doi: 10.1083/jcb.28.2.257.
2
The synthesis of DNA, RNA, and nuclear protein in normal and tumor strain cells. IV. HeLa tumor strain cells.正常细胞和肿瘤细胞系中DNA、RNA及核蛋白的合成。IV. 海拉肿瘤细胞系
J Cell Biol. 1966 Feb;28(2):263-75. doi: 10.1083/jcb.28.2.263.
3
The synthesis of DNA, RNA, and nuclear protein in normal and tumor strain cells. II. Fresh embryo mouse cells.正常细胞和肿瘤细胞系中DNA、RNA及核蛋白的合成。II. 新鲜胚胎小鼠细胞
J Cell Biol. 1966 Feb;28(2):249-56. doi: 10.1083/jcb.28.2.249.
4
Effect of x-irradiation on DNA synthesis in Ehrlich ascites carcinoma cells.X射线照射对艾氏腹水癌细胞DNA合成的影响。
Can J Biochem. 1965 Jul;43(7):859-64. doi: 10.1139/o65-098.
5
The synthesis of DNA, RNA, and nuclear protein in normal and tumor strain cells. I. Fresh embryo human cells.正常和肿瘤细胞系中DNA、RNA及核蛋白的合成。I. 新鲜人胚胎细胞
J Cell Biol. 1966 Feb;28(2):233-48. doi: 10.1083/jcb.28.2.233.
6
Antitumor agents LIII: The effects of daphnoretin on nucleic acid and protein synthesis of Ehrlich ascites tumor cells.抗肿瘤剂LIII：瑞香素对艾氏腹水癌细胞核酸和蛋白质合成的影响。
J Pharm Sci. 1982 Jul;71(7):741-4. doi: 10.1002/jps.2600710706.
7
[Effect of impulse laser radiation on the synthesis of nucleic acids and proteins in cancer cells].[脉冲激光辐射对癌细胞核酸和蛋白质合成的影响]
Radiobiologiia. 1983 Sep-Oct;23(5):668-70.
8
Inhibition and stimulation of the biosynthesis of protein and nucleic acid. IV. Effect of 2-amino-1,4-naphthoquinone imine on the biosynthesis of nucleic acid and protein in Ehrlich mouse ascites tumor cells in vitro.蛋白质和核酸生物合成的抑制与刺激。IV. 2-氨基-1,4-萘醌亚胺对体外艾氏小鼠腹水瘤细胞核酸和蛋白质生物合成的影响。
Chem Pharm Bull (Tokyo). 1969 May;17(5):1057-60. doi: 10.1248/cpb.17.1057.
9
Nucleic acids & protein synthesis in adenosine treated Ehrlich mouse ascites tumour cells.腺苷处理的艾氏小鼠腹水瘤细胞中的核酸与蛋白质合成
Indian J Exp Biol. 1975 May;13(3):290-2.
10
Inhibition of deoxyribonucleic acid synthesis in Ehrlich ascites cells by chloramphenicol.氯霉素对艾氏腹水癌细胞中脱氧核糖核酸合成的抑制作用。
Mol Pharmacol. 1977 May;13(3):504-11.
引用本文的文献
1
The synthesis of DNA, RNA, and nuclear protein in normal and tumor strain cells. IV. HeLa tumor strain cells.正常细胞和肿瘤细胞系中DNA、RNA及核蛋白的合成。IV. 海拉肿瘤细胞系
J Cell Biol. 1966 Feb;28(2):263-75. doi: 10.1083/jcb.28.2.263.
2
The synthesis of DNA, RNA, and nuclear protein in normal and tumor strain cells. II. Fresh embryo mouse cells.正常细胞和肿瘤细胞系中DNA、RNA及核蛋白的合成。II. 新鲜胚胎小鼠细胞
J Cell Biol. 1966 Feb;28(2):249-56. doi: 10.1083/jcb.28.2.249.
3
Induced changes in the rates of uridine- 3 H uptake and incorporation during the G 1 and S periods of synchronized Chinese hamster cells.在同步化的中国仓鼠细胞的G1期和S期期间，尿苷-3H摄取率和掺入率的诱导变化。
J Cell Biol. 1972 Mar;52(3):514-25. doi: 10.1083/jcb.52.3.514.
4
The use of zonal centrifugation to study membrane formation during the life cycle of mammalian cells. Synthesis of 'marker' enzymes and other components of cellular organelles.使用区带离心法研究哺乳动物细胞生命周期中的膜形成。细胞器“标记”酶和其他成分的合成。
Biochem J. 1970 Dec;120(4):683-8. doi: 10.1042/bj1200683.
5
Nucleic acids and protein biosynthesis during alkylation with triethylenemelamine in kb-cells.三乙烯三聚氰胺对kb细胞进行烷基化处理过程中的核酸与蛋白质生物合成
Z Krebsforsch. 1968;71(2):113-23. doi: 10.1007/BF00524343.
本文引用的文献
1
The effect of x-radiation on nuclear nucleotide content as studied by ultraviolet-microspectro-photometry on tumour cells.用紫外显微分光光度法研究X射线对肿瘤细胞核核苷酸含量的影响。
Exp Cell Res. 1962 Aug;27:321-5. doi: 10.1016/0014-4827(62)90235-5.
2
3
THE RELATIONS BETWEEN DNA, RNA, AND PROTEIN IN NORMAL EMBRYONIC CELL NUCLEI AND SPONTANEOUS TUMOUR CELL NUCLEI.正常胚胎细胞核与自发肿瘤细胞核中DNA、RNA和蛋白质之间的关系
J Cell Biol. 1964 Jan;20(1):17-23. doi: 10.1083/jcb.20.1.17.
4
Synthesis of ribonucleic acid, deoxyribonucleic acid and nuclear protein in normal and tumour strain cells.正常细胞和肿瘤细胞系中核糖核酸、脱氧核糖核酸及核蛋白的合成
Nature. 1963 Apr 13;198:147-53. doi: 10.1038/198147a0.
5
Action of radiation on mammalian cells. IV. Reversible mitotic lag in the S3 HeLa cell produced by low doses of x-rays.辐射对哺乳动物细胞的作用。IV. 低剂量X射线对S3海拉细胞产生的可逆性有丝分裂延迟
Proc Natl Acad Sci U S A. 1961 Aug;47(8):1181-91. doi: 10.1073/pnas.47.8.1181.
6
Cytochemical studies on some effects of x-radiation on three ascites tumors.关于X射线对三种腹水瘤某些作用的细胞化学研究。
Cancer Res. 1958 Aug;18(7):857-62.
7
Studies on the effect of x-rays on the biochemistry and cellular composition of ascites tumors. I. Effect on growth rate, cell volume, nucleic acid and nitrogen content in the Ehrlich ascites tumor.X射线对腹水肿瘤生物化学及细胞组成影响的研究。I. 对艾氏腹水瘤生长速率、细胞体积、核酸及氮含量的影响
Exp Cell Res. 1954 Feb;6(1):211-20. doi: 10.1016/0014-4827(54)90163-9.
8
Quantitative studies on the multiplication of neoplastic cells in vivo. I. Growth curves of the Ehrlich and MC1M ascites tumors.
J Natl Cancer Inst. 1953 Oct;14(2):229-77. doi: 10.1093/jnci/14.2.229.
9
The synthesis of DNA, RNA, and nuclear protein in normal and tumor strain cells. IV. HeLa tumor strain cells.正常细胞和肿瘤细胞系中DNA、RNA及核蛋白的合成。IV. 海拉肿瘤细胞系
J Cell Biol. 1966 Feb;28(2):263-75. doi: 10.1083/jcb.28.2.263.
10
The synthesis of DNA, RNA, and nuclear protein in normal and tumor strain cells. II. Fresh embryo mouse cells.正常细胞和肿瘤细胞系中DNA、RNA及核蛋白的合成。II. 新鲜胚胎小鼠细胞
J Cell Biol. 1966 Feb;28(2):249-56. doi: 10.1083/jcb.28.2.249.
Zotero 插件