Byck R
Lancet. 1976 Jul 10;2(7976):72-3. doi: 10.1016/s0140-6736(76)92289-3.
Actions of morphine include analgesia, sleep, euphoria, and depression of respiration. Transmitter or modulator substances in the brain that have actions similar to morphine may control these functions in man. This hypothesis proposes that enkephalin is a controlling neurotransmitter and its binding to opiate receptors determines mood state as well as influencing respiratory and sleep patterns. Lithium may act through modification of the opiate receptor affinity for an endogenous morphine-like substance. The theory predicts blocking action of naloxone in mania and in most drug-induced euphorias. It implies a new chemical pathophysiological basis for the phenomenology of mental illness.
吗啡的作用包括镇痛、助眠、欣快感和呼吸抑制。大脑中具有与吗啡相似作用的递质或调节物质可能控制人类的这些功能。该假说提出，脑啡肽是一种控制性神经递质，它与阿片受体的结合决定情绪状态，并影响呼吸和睡眠模式。锂可能通过改变阿片受体对一种内源性类吗啡物质的亲和力来发挥作用。该理论预测纳洛酮在躁狂症和大多数药物引起的欣快感中具有阻断作用。它暗示了精神疾病现象学的一种新的化学病理生理基础。
