Johnson E, Leask J T
J Endocrinol. 1977 Dec;75(3):363-72. doi: 10.1677/joe.0.0750363.
Roebucks have a specialized region of skin on the forehead which contains sebaceous and apocrine glands that produce secretions used in territorial marking. These glands enlarge during the breeding season and regress after the rut as the testes regress. The metabolism of testosterone by this forehead skin in vitro was studied in two captive roebucks over the period of glandular enlargement and subsequent regression, and compared with that of dorsal skin. In May, June and July, both areas of skin actively metabolized testosterone and the metabolites detected were androstenedione, androstanedione, dihydrotestosterone, epiandrosterone, androsterone and 5alpha-androstanediols. There were no major differences in testosterone metabolism between the two body sites, although dorsal skin appeared to be more active in total metabolism than forehead skin. There was a peak in the extent of metabolism in June/July, with a subsequent gradual decline to December. The decline in metabolism occurred at a time when the associated glands were still enlarged, which suggests that the availability of androgen to the skin glands is determined not only by the amount of testosterone in the circulation, but also by a decrease in the metabolizing capacity of the tissue.
狍子前额有一块特殊的皮肤区域，其中含有皮脂腺和顶泌腺，这些腺体分泌的物质用于领地标记。在繁殖季节，这些腺体会增大，发情期过后随着睾丸萎缩而退化。在两只圈养狍子的腺体增大及随后退化期间，研究了前额皮肤在体外对睾酮的代谢情况，并与背部皮肤进行了比较。在五月、六月和七月，两个皮肤区域都能积极代谢睾酮，检测到的代谢产物有雄烯二酮、雄烷二酮、双氢睾酮、表雄酮、雄酮和5α-雄烷二醇。两个身体部位在睾酮代谢方面没有显著差异，不过背部皮肤在总体代谢上似乎比前额皮肤更活跃。在六月/七月代谢程度达到峰值，随后逐渐下降至十二月。代谢下降发生在相关腺体仍处于增大状态时，这表明皮肤腺体中雄激素的可利用性不仅取决于循环中睾酮的含量，还取决于组织代谢能力的下降。
